摘要
目的探究泌乳素与肉芽肿性乳腺炎(GM)发生以及预后之间的关系。方法选取东莞市人民医院2016年1月—2019年12月期间收治的237例GM患者作为研究组,选取同期100名健康体检者作为对照组,均测定血清泌乳素,比较2组血清泌乳素水平,分析患者血清泌乳素水平与临床特征之间关系,研究组患者在治疗后评估预后情况,比较不同预后患者血清泌乳素水平并分析血清泌乳素对GM预后预测价值。结果研究组患者血清泌乳素水平高于对照组,差异比较有统计学意义(P<0.05);患者血清泌乳素水平与近期5年是否足月妊娠、是否服用避孕药有关(P<0.05);预后不佳患者血清泌乳素水平显著高于预后良好患者(P<0.05);ROC曲线显示,血清泌乳素用于预测GM患者预后不良曲线下面积为0.799(95%CI:0.733~0.866),处于最佳截断值处灵敏度与特异度分别为86.2%和85.2%。结论GM患者泌乳素水平异常上升,且与患者临床特征以及预后关系密切,用于预测患者预后价值优异。
Objective This study was conducted to explore the relationship between prolactin and the occurrence and prognosis of granulomatous mastitis(GM).Methods 237 GM patients(study group)and 100 healthy people(control group)were enrolled in this study between January 2016 and December 2019.Serum prolactin was measured and compared between the 2 groups.The relationship between serum prolactin level and clinical characteristics and prognosis of GM was analyzed.Results It was found that the study group had higher serum prolactin levels than the control group(P<0.05),and serum prolactin level was related to full-term pregnancy in the recent 5 years,and use of oral contraceptives(P<0.05).Besides,patients with poor prognosis had significantly higher serum prolactin levels than those with good prognosis(P<0.05).ROC curve showed that the area under the curve of serum prolactin for predicting poor prognosis of GM patients was 0.799(95%CI:0.733-0.866),and the sensitivity and specificity at the best cut-off value were 86.2%and 85.2%,respectively.Conclusion GM patients have abnormally elevated prolactin levels,which is closely related to clinical characteristics and prognosis of the patients,suggesting that the prolactin level can be used for prognosis prediction.
作者
陈丽娟
高学忠
曹茵
袁惠玲
陈桂林
Chen Lijuan;Gao Xuezhong;Cao Yin;Yuan Huiling;Chen Guilin(The Dongguan People's Hospital Puji Branch,Dongguan,Guangdong 523000)
出处
《基层医学论坛》
2023年第25期23-25,共3页
The Medical Forum
关键词
肉芽肿性乳腺炎
预后
泌乳素
Granulomatous mastitis
Prognosis
Prolactin