摘要
目的设计一种新型射频组织焊接电极,提高吻合口生物力学强度的同时减少组织热损伤。方法设计表面存在镂空结构的新型电极(梅花形电极),以环形电极作为对照组,在射频能量作用下完成肠道组织焊接,通过撕脱力和爆破压测试研究焊接吻合口的生物力学特性,采用有限元电-热-力多场耦合仿真分析和热电偶探针研究焊接过程中的组织热损伤,并对微观组织结构进行检查。结果当焊接功率120 W、焊接时间8 s、压合压强20 kPa时,肠道吻合口呈现最优的生物力学特性。与环形电极对照组相比,梅花形电极组吻合口生物力学强度更高,撕脱力和爆破压分别从(8.62±1.22)N、(81.7±3.36)mmHg增加到(9.54±1.24)N、(89.4±4.15)mmHg,且组织热损伤显著减少,组织微观结构连接更为紧密。结论该新型电极在提高吻合口生物力学强度的同时可减少组织热损伤,进而实现更好的吻合效果。研究结果可为实现人体管腔组织的无缝连接提供参考。
Objective Aiming at improving biomechanical strength of the anastomotic stoma as well as reducing tissue thermal damage,a novel radiofrequency(RF)tissue welding electrode was developed.Methods A novel electrode with a hollow structure on the surface(the plum electrode)was designed and the ring electrode was used as control group to conduct the welding of intestinal tissues based on RF energy.Biomechanical properties of anastomotic stoma were studied by shear test and burst pressure test.The tissue thermal damage during welding was investigated by finite element electro-thermal-mechanical multi-field coupling simulation analysis and thermocouple probe,and the tissue microstructures were also studied.Results Under 120 W RF energy,8 s welding duration and 20 kPa compression pressure,the anastomotic stoma had the optimal biomechanical properties.Compared with the ring electrode group,biomechanical strength of the anastomotic stoma in plum electrode group was higher,with the shear strength and burst pressure increasing from(9.7±1.47)N,(84.0±5.99)mmHg to(11.1±1.71)N,(89.4±6.60)mmHg,respectively.There was a significant reduction in tissue thermal damage,and intact and fully fused stomas could be formed in anastomotic area.Conclusions The proposed novel electrode could improve biomechanical strength of the anastomosis as well as reduce tissue thermal damage,thus achieve better fusion.The research result provide references for realizing the seamless connection of human lumen tissues.
作者
邢绪坡
胡钟欣
韩正一
宋成利
毛琳
XING Xupo;HU Zhongxin;HAN Zhengyi;SONG Chengli;MAO Lin(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)
出处
《医用生物力学》
CAS
CSCD
北大核心
2023年第3期601-607,共7页
Journal of Medical Biomechanics
基金
科技部国家重点研发计划项目(2019YFC0120402)
国家自然科学基金项目(51901137,51735003)。
关键词
射频组织焊接
新型电极
肠道吻合
组织热损伤
radiofrequency tissue fusion
novel electrode
intestinal anastomosis
tissue thermal damage
