摘要
目的 分析三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)与精神分裂症(SZ患者精神症状的相关性。方法 选取2020年6月至2023年2月江西省荣军优抚医院收治的74例SZ患者,作为SZ组;另选取同期医院健康体检者74名,作为对照组;采用阳性及阴性综合征量表(PANSS)对受试者精神症状进行评估,并检测全部受试者血清T3、T4、TSH水平;经Pearson相关性分析T3、T4、TSH水平与SZ患者精神症状的相关性;绘制受试者工作特征(ROC)曲线,分析T3、T4、TSH水平评估SZ患者中重度精神症状程度的价值。结果 SZ组血清T3、T4、TSH水平均低于对照组,差异有统计学意义(P<0.05);74例SZ患者经评估,PANSS评分为(112±14)分;其中阳性、阴性症状及一般精神病理得分(23±4)分、(28±4)分、(61±6)分。74例SZ患者中,有31例为轻度症状,43例为中重度症状。T3、T4与SZ患者阴性症状呈负相关(r=-0.456、-0.511,P<0.05);TSH水平与阴性症状呈正相关(r=0.392,P<0.05);T3、T4、TSH与SZ患者阳性症状、一般精神病理无相关性(P>0.05)。中重度程度的SZ患者T3、T4、TSH低于轻度组(P<0.05);绘制ROC曲线,T3评估SZ患者中重度精神症状程度有一定价值,曲线下面积(AUC)>0.71,但T4、TSH水平评估价值较差,AUC<0.70。结论 SZ患者T3、T4、TSH水平偏低,与阴性症状有一定相关性。
Objective To analyze the correlation between triiodothyronine(T3),thyroxine(T4),thyroid-stimulating hormone(TSH)and psychiatric symptoms in patients with schizophrenia(SZ).Methods Seventy-four patients with SZ admitted to Jiangxi Rongjun Youfu Hospital from June 2020 to February 2023 were selected as the SZ group;another 74 patients who underwent health checkups in the hospital during the same period were also selected as the control group;the positive and negative syndrome scale(PANSS)was used to assess the psychiatric symptoms of the subjects,and serum levels of T3,T4,and TSH were detected in all of them;after Pearson correlation analysis of the correlation between T3,T4,and TSH levels and the psychiatric symptoms of SZ patients;plotting the subjects′work characteristics(ROC)curves,and analyzing the value of T3,T4,and TSH levels in assessing the degree of moderate-to-severe psychiatric symptoms in SZ patients.Results Serum T3,T4,and TSH levels in the SZ group were lower than those in the control group,and the difference was statistically significant(P<0.05);Seventy-four SZ patients were assessed with a positive and negative symptom scale(PANSS)score of(112±14);of these,the positive,negative symptom and general psychopathology scores were(23±4),(28±4),and(61±6)points.Of the 74 SZ patients,thirty-one patients had mild symptoms and 43 had moderately severe symptoms.T3 and T4 levels were negatively correlated with negative symptoms in SZ patients(r=-0.456,-0.511,P<0.05);TSH levels were positively correlated with negative symptoms(r=0.392,P<0.05);T3,T4 and TSH levels were not correlated with positive symptoms and general psychopathology in SZ patients(P>0.05).The T3,T4,and TSH levels of SZ patients with moderate-to-severe degree were lower than those of the mild group(P<0.05);plotting the ROC curve,the T3 level had some value in assessing the degree of moderate-to-severe psychiatric symptoms in SZ patients,with an area under the curve(AUC)of>0.71,but the T4 and TSH levels had poorer value in assessing the degree of severe psychiatric symptoms,with an AUC of<0.70.Conclusion There was a certain correlation between low levels of T3,T4,and TSH in SZ patients and negative symptoms.
作者
蒋玉娟
徐霞
林春峰
Jiang Yujuan;Xu Xia;Lin Chunfeng(Department of Laboratory,Jiangxi Rongjun Youfu Hospital,Nanchang Jiangxi 330199,China)
出处
《实用医技杂志》
2023年第3期175-178,共4页
Journal of Practical Medical Techniques
