摘要
目的:探讨中医益肺健脾化痰法联合金字塔模式治疗肺癌术后咳嗽的疗效和对炎症反应、免疫功能、营养状态的调节作用。方法:选取2019年9月—2021年12月本院胸腔镜肺癌术后咳嗽患者76例作为研究对象,随机分成两组。对照组38例,采用金字塔模式下围手术期治疗,观察组38例在对照组相同治疗基础上加用中医益肺健脾化痰法。采用视觉模拟评分(VAS)和简易咳嗽程度评分表(CET))评估治疗咳嗽的效果。通过比较两组患者炎症因子(TNF-α、IL-6、IL-10、CRP)、淋巴细胞亚群(CD^(+)_(4)、CD^(+)_(8)、CD^(+)_(4)/CD^(+)_(8)、血清蛋白(PA、TF、ALB)等指标评估炎症反应、免疫功能及营养状态变化。监测肝肾功能评估药物的安全性。结果:治疗后观察组咳嗽VAS评分为(0.98±0.47)分、CET评分为(8.18±2.08)分,均低于对照组(P<0.05)。治疗后观察组炎症因子TNF-α(6.34±2.41)ng/L、IL-6(9.50±3.30)ng/L、CRP(4.05±1.06)mg/L均低于对照组(P<0.05),IL-10(25.32±3.41)ng/L高于对照组(P<0.05)。治疗后观察组CD^(+)_(4)(38.66±4.82)%和CD^(+)_(4)/CD^(+)_(8)(1.55±0.35)高于对照组(P<0.05)。治疗后观察组营养指标PA(200.92±31.24)mg/L、TF(2.76±0.66)g/L、ALB(38.32±3.40)g/L均高于对照组(P<0.05)。治疗期间两组患者均未发生肝肾功能损害。结论:中医益肺健脾化痰法联合金字塔模式治疗肺癌术后咳嗽效果良好,也有助于增强免疫力,减轻炎症反应,改善营养状态。
Objective:To investigate the effects of Yifei Jianpi Huatan Method combined with the pyramidal model in treating postoperative cough in lung cancer patients,and the modulating effect on inflammatory res-ponse,immune function and nutritional status.Methods:76 patients with postoperative cough after thoracoscopic lung cancer in our hospital from September 2019 to December 2021 were selected as study subjects and randomly divided into two groups.In the control group,38 cases were treated with perioperative treatment under the pyramidal model,and in the observation group,38 cases were treated with the same treatment as the control group with the addition of Chinese medicine of Yifei Jianpi Huatan Method.The visual analogue score(VAS)of cough and simple cough extent scale(CET)were used to compare the changes of cough severity in the two groups.Changes in inflammatory response,immune function and nutritional status were assessed by comparing inflammatory factors(TNF-α,IL-6,IL-10,CRP),lymphocyte subsets(CD^(+)_(4),CD^(+)_(8),CD^(+)_(4)/CD^(+)_(8)),and serum proteins(PA,TF,ALB)in the two groups were determined before and after treatment,Liver and kidney functions were monitored to assess the safety of the drugs.Results:The VAS score(0.98±0.47)of cough and CET score(8.18±2.08)in the observation group were lower than those in the control group after treatment(P<0.05).The inflammatory factors TNF-α(6.34±2.41)ng/L,IL-6(9.50±3.30)ng/L and CRP(4.05±1.06)mg/L were lower in the observation group than those in the control group after treatment(P<0.05),and IL-10(25.32±3.41)ng/L was higher than that in the control group(P<0.05).CD^(+)_(4)(38.66±4.82)%and CD^(+)_(4)/CD^(+)_(8)(1.55±0.35)were higher in the observation group than those in the control group after treatment(P<0.05).Nutritional indicators PA(200.92±31.24)mg/L,TF(2.76±0.66)g/L and ALB(38.32±3.40)g/L were higher in the observation group than those in the control group after treatment(P<0.05).No liver or kidney function damage occurred in both groups during treatment.Conclusion:Yifei Jianpi Huatan Method combined with the pyramid model is effective in treating postoperative cough in lung cancer and also helps to enhance immunity,alleviate inflammation reaction and improve the nutritional state.
作者
刘锐
王海明
孙平
徐俊
LIU Rui;WANG Haiming;SUN Ping;XU Jun(Department of Thoracic Surgery,Third People’s Hospital of Hangzhou,Hangzhou,Zhejiang 310009)
出处
《中国中医药科技》
CAS
2023年第5期845-848,共4页
Chinese Journal of Traditional Medical Science and Technology
基金
浙江省中医药优秀青年人才基金项目(2020ZQ044)。
关键词
益肺健脾化痰法
肺癌术后咳嗽
免疫功能
炎性因子
营养状态
Yifei Jianpi Huatan Method
postoperative cough of lung cancer
immune function
inflammatory factor
nutritional state
