摘要
炎症是多种疾病的基本病理过程,其参与女性不孕相关疾病的发生发展,尤其常见于细菌、病毒引起生殖系统的感染,从而导致不孕。然而,在女性正常的生理过程,如子宫内膜的周期性变化、卵泡生成、排卵、黄体形成、妊娠等过程中同样存在炎症反应及炎症因子的参与。此外,炎症也参与了一些生殖内分泌和代谢性疾病的发生,比如肥胖、子宫内膜异位症、多囊卵巢综合征等。我们以往对生殖系统炎症的认知,多局限于生殖系统的炎性疾病以及由此造成的生育力下降或不孕、不育等问题,但这并不全面。现对生殖系统中正常生理性炎症和疾病相关性炎症进行详细综述,并提出炎症状态的评估,以及给予相关的防治建议。
Inflammation is the basic pathological process of a variety of diseases,which involved in the occurrence and development of female infertility-related diseases,especially in bacteria and viruses infection of reproductive system,resulting in infertility.However,inflammatory reactions and factors also exist in normal physiological processes,such as endometrial morphologic changes in menstrual cycles,follicle genesis,ovulation,luteinization,pregnancy,etc.In addition,inflammation is also involved in the occurrence of some reproductive endocrine and metabolic diseases,such as obesity,endometriosis,polycystic ovary syndrome and so on.In the past,the understanding to inflammation in reproductive system was mostly limited to the inflammatory diseases and resulted in fertility decline or sterility,infertility,and other problems,which was not comprehensive.This review summarized the normal physiological inflammation and disease-related inflammation in the reproductive system,and described the evaluation of inflammatory state,as well as relevant prevention and treatment suggestions.
作者
董香华
刘佳佳
高明霞
Xianghua Dong;Jiajia Liu;Mingxia Gao(The First Clinical Medical College of Lanzhou University,Lanzhou,730000,China;Reproductive Medicine Center,The First Hospital of Lanzhou University,Lanzhou,730000,China)
出处
《中国综合临床》
2023年第4期316-320,共5页
Clinical Medicine of China
基金
甘肃省自然科学基金项目(18JR3RA304)。
关键词
炎症
生殖
代谢
Inflammation
Reproduction
Metabolism
