摘要
以(S)-2-(叔丁氧羰基氨基)丁酸和2-氨基-6-氟苯甲酸为起始原料,经环合,然后与苯胺反应,再在盐酸的作用下,脱Boc、成盐酸盐,即得(S)-2-(1-氨基丙基)-5-氟-3-苯基-4(3H)-喹唑啉酮盐酸盐。目标产物经核磁共振氢谱(^(1)H NMR)、碳谱(^(13)C NMR)、质谱(MS)、红外光谱(IR)进行了表征,再经挥发得到了本品的单晶,并通过X单晶衍射分析表征了其结构。
The title compound was synthesized by using 2-amino-6-fluoro-benzonic acid(2)and(S)-2-((tert-butoxycarbonyl)amino]butanoic acid(5)as starting materials,giving(S)-tert-butyl(1-(5-fluoro-4-oxo-4 H-benzo[d][1,3]oxazin-2-yl)propyl)carbamate via cyclization reaction(3)followed by reacting with aniline to afford(S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate(4).The title compound,(S)-2-(1-aminopropyl)-5-fluoro-3-phenyl-3 H-quinazolin-4-one hydrochloride(1),was prepared by treating with hydrochloride acid(HCl).Compound 1 was characterized by^(1)H NMR,^(13)C NMR,MS,IR and single crystal X-ray crystallography.
作者
吴云登
龚飞虎
万辉
谢俊
徐向阳
李剑
Wu Yundeng;Gong Feihu;Wan Hui;Xie Jun;Xu Xiangyang;Li Jian(Technique Center,Jinling Pharmaceutical Company Limited,Nanjing,Jiangsu 210046,China;Regenecore Company Limited,Nanjing,Jiangsu 210032,China)
出处
《化学世界》
CAS
2023年第5期359-364,共6页
Chemical World
