摘要
Cajal间质细胞是一类具有独特超微结构、分子表型和功能的不同类别的细胞,其主要功能是产生慢波,从而引发胃肠起搏,调控胃肠运动。它们在协调消化系统的正常活动方面具有极为重要的生理作用,其数量、形态及功能异常等往往对胃肠动力造成一定影响。功能性胃肠病是一类与胃肠运动功能密切相关的消化系统疾病,相关研究表明功能性胃肠病的发病与Cajal间质细胞的数量、形态及功能异常密切相关,而中医药可通过调控Cajal间质细胞形态及数量、维持胃肠电生理的正常运转、抑制其过度自噬及激活相关信号通路等改善胃肠动力,从而治疗功能性胃肠病。本文将从中药复方、中药单体、中医外治法调控Cajal间质细胞治疗功能性胃肠病进行论述。
Interstitial cells of Cajal are a different class of cells with unique ultrastructure,molecular phenotype and func⁃tion,and their main function is to generate slow waves,thereby triggering gastrointestinal pacing and regulating gastrointestinal motility.They play an extremely important physiological role in coordinating the normal activities of the digestive system,and their number,shape and function abnormalities often have a certain impact on gastrointestinal motility.Functional gastrointestinal disease is a type of digestive system disease closely related to gastrointestinal motility.Relevant studies have shown that the patho⁃genesis of functional gastrointestinal disease is closely related to the abnormal number,morphology and function of Cajal intersti⁃tial cells.Regulating the shape and number of interstitial cells of Cajal,maintaining the normal operation of gastrointestinal electro⁃physiology,inhibiting excessive autophagy and activating related signaling pathways etc.,can improve gastrointestinal motility,thereby treating functional gastrointestinal diseases.This article discusses the treatment of functional gastrointestinal diseases from traditional Chinese medicine compound,traditional Chinese medicine monomer,and external treatment of traditional Chinese med⁃icine by regulating Cajal interstitial cells.
作者
韦熔煌
梁雅琳
黄学霞
蒙华莹
黄茂光
罗峰
谢胜
WEI Rong-huang;LIANG Ya-lin;HUANG Xue-xia;MENG Hua-ying;HUANG Mao-guang;LUO Feng;XIE Sheng(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530001,China)
出处
《海南医学院学报》
2023年第17期1346-1352,1360,共8页
Journal of Hainan Medical University
基金
广西中医脾胃病临床医学研究中心(桂科AD19245168)。
关键词
中医药
CAJAL间质细胞
功能性胃肠病
Traditional Chinese medicine
ICC
Functional gastrointestinal disease
