摘要
糖尿病心肌病(DCM)是排除高血压、冠心病、瓣膜病、先天性心脏病等其他心血管疾病后的特异性心肌病,其发病机制是目前的研究热点。糖尿病患者由于糖脂代谢失衡、氧化应激增加、多种炎症反应激活,可造成心肌细胞和细胞外损伤,最终发生病理性心肌重构,临床表现为舒张和(或)收缩功能障碍,最终发展为糖尿病性心力衰竭。目前,DCM的早期筛查手段和治疗方法仍然有限。为更好地了解DCM发生、发展的具体机制,本文就DCM的病理生理机制、临床表现及治疗前景的最新研究进展进行综述,以期为临床早期防治DCM提供参考。
Diabetic cardiomyopathy(DCM)is a specific cardiomyopathy,independent of hypertension,coronary heart disease,valvular disease,congenital heart disease or other cardiovascular diseases.The pathogenesis of DCM is one of the current research hot spots in recent years.Due to the imbalance of glucose and lipid metabolism,the increase of oxidative stress and the activation of various inflammatory reactions,further mediating the myocardial cell and extracellular damage,resulting in pathological myocardial remodeling,diastolic and systolic dysfunction and eventually evolving into heart failure.At present,the effective methods for early screening and treatment of DCM are still limited.In order to better understand the specific mechanism of the occurrence and development of DCM,the latest research progress on pathophysiological mechanism,clinical manifestation and therapeutic prospect of DCM were reviewed for providing reference for the early clinical prevention and treatment of DCM.
作者
陈艳艳
周洁
卢作维
李梦颖
马溪悦
李晓苗
Chen Yan-Yan;Zhou Jie;Lu Zuo-Wei;Li Meng-Ying;Ma Xi-Yue;Li Xiao-Miao(Department of Endocrinology,the First Affiliated Hospital of Air Force Medical University,Xi'an,Shaanxi 710033,China;Medical Imaging of Xi'an Medical University,Xi'an,Shaanxi 710021,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2023年第8期957-964,共8页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金面上项目(82070839)
陕西省基础研究计划重点项目(S2020-JC-ZD-0042)。
关键词
糖尿病心肌病
发病机制
心功能障碍
心力衰竭
治疗前景
diabetic cardiomyopathy
pathogenesis
cardiac dysfunction
heart failure
treatment prospect
