摘要
目的探讨慢性鼻窦炎并发鼻息肉患者应用低剂量罗红霉素治疗的临床价值及症状的改善效果。方法于2020年7月至2022年6月采集病例展开研究,对象为医院收治且经严格筛选后的100慢性鼻窦炎并发鼻息肉患者,在随机原则下进行分组—对照组、观察组,各50例,对照组应用常规药物治疗,观察组应用低剂量罗红霉素治疗;根据症状改善及疾病转归情况,评估临床疗效,评估患者头痛、鼻塞、流涕、嗅觉减退等症状改善情况,使用鼻阻力计测量鼻腔通气阻力,检测炎症水平变化,利用健康调查简表(SF-36)判定患者治疗前后的生活质量。结果与对照组相比,观察组临床有效率更高,且经治疗后,观察组的临床症状评分相对低(P<0.05);两组治疗前鼻腔总阻力比较差异无统计学意义(P>0.05),经治疗后,两组鼻腔总阻力均呈不同程度下降,且观察组下降幅度更显著(P<0.05);治疗后,两组TNF-α、IL-8水平均呈不同程度下降,且观察组下降幅度更为显著(P<0.05);治疗后,观察组SF-36各维度评分高于对照组(P<0.05)。结论应用低剂量罗红霉素治疗慢性鼻窦炎并发鼻息肉患者,对改善患者头痛、嗅觉减退等临床症状发挥显著作用,同时还能起到降低鼻腔阻力、改善鼻通气的效果,临床疗效确切,促使患者生活质量大幅度提升。
Objective To investigate the clinical value of low-dose roxithromycin in the treatment of chronic sinusitis complicated with nasal polyps and the improvement of symptoms.Methods From July 2020 to June 2022,100 cases of chronic sinusitis complicated with nasal polyps were collected and studied.The subjects were 100 patients with chronic sinusitis complicated with nasal polyps who were admitted to the hospital and treated strictly.They were randomly divided into control group and observation group,with 50 cases in each group.The former group was treated with conventional drugs,and the latter group was treated with low-dose roxithromycin.According to the improvement of symptoms and the outcome of the disease,evaluate the clinical efficacy,the improvement of headache,nasal congestion,runny nose,hypoesthesia and other symptoms of the patients,measure the nasal ventilation resistance with a nasal resistance meter,detect the changes in the level of inflammation,and determine the quality of life of patients before and after treatment using the 36-item short form Health Survey(SF-36).Results Compared with the control group,the statistical data of clinical effective rate was higher in the observation group,and the clinical symptom score of the observation group was relatively low after treatment(P<0.05).After treatment,the total nasal resistance of the observation group was significantly lower than that of the control group(P<0.05).Compared with before treatment,after treatment,two groups of inflammatory factor indicators,namely TNF-α、IL-8 water decreased on average,and the observation group was more significant(P<0.05).After treatment,the SF-36 scores in the observation group was more significant higher than the control group(P<0.05).Conclusion The application of low-dose roxithromycin in the treatment of patients with chronic sinusitis complicated with nasal polyps plays a significant role in improving the clinical symptoms of patients with headache,hypoesthesia,and can also reduce nasal resistance and improve nasal ventilation.The clinical effect is accurate,and the quality of life of patients is greatly improved.
作者
李华荣
LI Huarong(Department of Otolaryngology Head and Neck Surgery,Jianyang First Hospital,Nanping 354200,China)
出处
《中国医药指南》
2023年第25期98-100,104,共4页
Guide of China Medicine
关键词
慢性鼻窦炎
鼻息肉
低剂量
罗红霉素
症状缓解
Chronic sinusitis
Nasal polyp
Low dose
Roxithromycin
Symptom relief
