摘要
聚甲基丙烯酸甲酯(PMMA)骨水泥因具有良好的力学性能、适宜的凝固时间和低毒性等优点而在骨科手术中作为可注射型人工骨修复材料受到广泛的应用。然而,其生物惰性可能导致假体长期植入后产生无菌性松动。本研究采用模板法制备了介孔硼硅酸盐生物玻璃微球(MBGS),并用硅烷偶联剂γ-甲基丙烯酰氧基丙基三甲氧基硅烷(γ-MPS)对其进行改性,制备了MBGSSI。再将硅烷化介孔硼硅酸盐生物玻璃微球(MBGSSI)与聚甲基丙烯酸甲酯(PMMA)骨水泥复合,制备了一种具有良好生物活性和力学性能的复合骨水泥。实验结果表明,由于γ-MPS与MBGS的结合主要发生在介孔微球的近表面,MBGSSI比MBGS具有更大的比表面积和更小的孔容积。与MBGS/PMMA复合骨水泥相比,γ-MPS可以改善复合材料中无机相和有机相之间的结合,因此MBGSSI/PMMA复合骨水泥的力学性能得到了改善,符合ISO 5833:2002对丙烯酸类骨水泥的力学性能要求。此外,在SBF溶液中浸泡42 d后,MBGS/PMMA和MBGSSI/PMMA复合骨水泥的表面均生成了羟基磷灰石(HA),证明复合骨水泥具有良好的生物活性。因此,MBGSSI/PMMA复合骨水泥是一种潜在的骨修复材料。
Poly(methyl methacrylate)(PMMA)bone cement is widely used in orthopaedic surgery as an injectable artificial bone repair material due to its advantages such as desirable mechanical properties,suitable curing time and low toxicity.However,its bioinert polymer may lead to aseptic loosening of the prostheses after long-term implantation.Here,silanized mesoporous borosilicate bioglass microspheres(MBGSSI)composite with PMMA bone cement was prepared to obtain ideal bone repair material with desirable bioactivity and mechanical properties.Mesoporous borosilicate bioglass microspheres(MBGS)were prepared by template method and modified by silane coupling agentγ-methylacryloxy propyl trimethoxysilane(γ-MPS)to obtain MBGSSI.The results indicated that MBGSSI possessed increased specific surface area and decreased total pore volume than MBGS did by the binding betweenγ-MPS and MBGS occurred on the near surface of mesoporous microspheres.Compared with MBGS/PMMA,MBGSSI/PMMA composite bone cements demonstrated improved mechanical properties,which met the mechanical properties requirements of ISO 5833:2002 becauseγ-MPS improved the combination between inorganic and organic phases of composite.In addition,the hydroxyapatite(HA)could widely form on the surface of both MBGS/PMMA and MBGSSI/PMMA composite bone cements after immersing in SBF for 42 d,demonstrating the excellent bioactivity.Hence,it is suggested that MBGSSI/PMMA can be a potential bone repair material.
作者
倪晓诗
林子扬
秦沐严
叶松
王德平
NI Xiaoshi;LIN Ziyang;QIN Muyan;YE Song;WANG Deping(School of Materials Science and Engineering,Tongji University,Shanghai 201804,China)
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2023年第8期971-977,共7页
Journal of Inorganic Materials
基金
National Natural Science Foundation of China(52172286)
National Key R&D Program of China(2018YFC1106302)。
