摘要
成体神经发生在哺乳动物大脑中持续存在,新生神经元能够整合到已有神经网络并参与调节神经网络兴奋性。在增龄性相关的神经退行性疾病发生发展过程中,成体神经发生易受局部微环境的影响,成体神经发生异常与神经退行性疾病患者的焦虑、抑郁和认知障碍密切相关。本文系统性总结神经退行性疾病(阿尔茨海默病、帕金森病和亨廷顿病)患者和动物模型的成体神经发生异常的病理机制,探讨靶向调控成体神经发生在衰老相关的神经退行性疾病中的应用效果,为预防和治疗神经退行性疾病提供新的思路和方法。
Adult neurogenesis(ANG)exists in almost all mammalian brains,and newborn neurons can integrate into the existing neural network and participate in regulating the excitability of the neural network.ANG is vulnerable to the pathologic microenvironment in the development of age-related neurodegenerative diseases.Aberrant ANG correlates with depression,anxiety and cognition decline in patients with neurodegenerative diseases.In this review,we summarize the study on the mechanism underlying aberrant ANG and the effects of modulating ANG on neurodegenerative diseases(Alzheimer's disease,Parkinson's disease,Huntington's disease),thus providing new insights into or therapy targets for neurodegenerative diseases.
作者
李雨恒
陈文政
刘启航
王湜
梅宇飞
LI Yu-Heng;CHEN Wen-Zheng;LIU Qi-Hang;WANG Shi;MEI Yu-Fei(Brain Science and Advanced Technology Institute,Wuhan University of Science and Technology,Wuhan 430065,China;Hubei Province Key Laboratory of Occupational Hazard Identification and Control,Wuhan 430065,China)
出处
《生命科学》
CSCD
北大核心
2023年第8期1004-1011,共8页
Chinese Bulletin of Life Sciences
基金
湖北省大学生创新创业训练计划项目(S202110488071):职业危害识别与控制湖北省重点实验室开放基金项目(0HIC2021Z07)
国家自然科学基金青年项目(82201351)。
关键词
神经发生
阿尔茨海默病
帕金森病
亨廷顿病
neurogenesis
Alzheimer's disease
Parkinson's disease
Huntington's disease
