摘要
目的探讨康派特组织粘合胶粘合巴马小型猪皮肤切口的有效性,并与Histoacryl医用组织胶水进行比较。方法选用8只巴马小型猪,按性别和体重随机分为A、B两组,每组4只,雌雄各半。A组术后1周剖检,B组术后4周剖检。采用同体左右侧自身对比法,先于实验动物背部两侧皮肤制作切口模型,然后分别采用康派特组织粘合胶和Histoacryl医用组织胶水粘合切口。观察实验动物的临床症状、体重、摄食量、切口局部症状,并对切口部位组织进行组织病理学检查。结果术后实验动物的临床症状、体重、摄食量均未见明显异常。涂胶当天两侧切口局部可见轻度红斑,刺激强度为轻度,术后第1天开始肉眼已观察不到两侧皮肤刺激,刺激强度为极轻微。组织病理学检查结果显示,术后1周实验动物涂胶部位均可见极轻度或轻度的炎性细胞浸润、出血、轻度至中度的纤维组织增生等组织病理学改变。术后4周实验动物手术部位可见不同程度组织修复,未见明显皮肤刺激反应。结论该实验条件下,康派特组织粘合胶粘合巴马小型猪皮肤切口安全有效,且与Histoacryl医用组织胶水比较未见明显差异。
Objective To explore the effectiveness of Compont tissue adhesive in bonding skin incisions in Bama miniature pigs,and compared with Histoacrel medical tissue adhesive.Methods Eight Bama miniature pigs were selected,the pigs were randomly divided into groups A and B based on gender and weight,with 4 pigs in each group,half male and half female.Group A was dissected 1 week after surgery,while Group B was dissected 4 weeks after surgery.The method of self comparison on the left and right sides of the same body was used,a incision model was first made on the skin on both sides of the experimental animal's back,and then the incision was bonded using Compont tissue adhesive and Histoacryl medical tissue adhesive,respectively.The clinical symptoms,body weight,food intake,and local symptoms of the incision of the experimental animals were observed,and histopathological examinations were performed on the tissue at the incision site.Results There were no significant abnormalities in the clinical symptoms,weight,and food intake of the experimental animals after surgery.On the day of gluing,mild erythema can be seen in the local incisions on both sides,with a mild irritation intensity.From the first day after surgery,skin irritation on both sides can no longer be observed with the naked eye,and the irritation intensity is extremely mild.The histopathological examination results showed that all experimental animals showed extremely mild or mild inflammatory cell infiltration,bleeding,and mild to moderate fibrous tissue hyperplasia at the gelation site one week after surgery.At 4 weeks after surgery,different degrees of tissue repair were observed at the surgical site of the experimental animals,and no significant skin irritation was observed.Conclusion Under this experimental condition,Compont tissue adhesive is safe and effective in bonding the skin incision of Bama miniature pigs,and there is no significant difference compared to Histacryl medical tissue adhesive.
作者
卜文
刘文谦
李彦
刘超
丛源
沈连忠
Bu Wen;Liu Wenqian;Li Yan;Liu Chao;Cong Yuan;Shen Lianzhong(Shandong Xinbo Pharmaceutical R&D,Ltd.,Linyi Shandong 251500,China)
出处
《医疗装备》
2023年第17期20-25,共6页
Medical Equipment
