摘要
目的:观察枳实大黄汤加减联合针刺疗法对急性期脑梗死患者炎性反应、神经功能的影响。方法:选取2020年3月至2022年3月商丘市中医院诊治的急性期脑梗死患者96例,按照随机数字表法分为联合治疗组和常规治疗组,每组48例。常规治疗组给予阿托伐他汀钙片治疗,联合治疗组在常规治疗组治疗的基础上加用枳实大黄汤加减联合针刺疗法治疗。观察两组患者治疗前后血清炎性因子[肿瘤坏死因子(tumor necrosis factor,TNF)-α、白细胞介素(interleukin,IL)-6、IL-8、超敏C-反应蛋白(hs-C reactive protein,hs-CRP)]、脑动力学指标、神美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、病情转归程度(modified rankin scale,mRS)量表评分、生活质量(SF-36)评分变化情况及临床疗效。结果:联合治疗组有效率为93.75%,常规治疗组有效率为77.08%,联合治疗组有效率高于常规治疗组,差异有统计学意义(P<0.05);联合治疗组治疗后血清TNF-α、IL-6、IL-8、hs-CRP水平低于常规治疗组,差异有统计学意义(P<0.05);联合治疗组治疗后Vp、Vm高于常规治疗组,差异有统计学意义(P<0.05);联合治疗组治疗后NIHSS评分、mRS评分低于常规治疗组,差异有统计学意义(P<0.05);联合治疗组治疗后生活质量各项评分高于常规治疗组,差异有统计学意义(P<0.05)。结论:枳实大黄汤加减联合通脑活络针刺法能提高急性期脑梗死患者的临床治疗效果,减轻机体炎性程度,促进神经功能恢复,提高生活质量。
Objective:To observe the influence of Modified Immature Bitter Orange and Rhubarb Decoction combined with acupuncture on inflammatory response and nerve function in patients with acute cerebral infarction.Methods:A total of 96 patients with acute cerebral infarction diagnosed and treated in Shangqiu Hospital of Traditional Chinese Medicine from March 2020 to March 2022 were selected and divided into the combined treatment group and the conventional treatment group according to the random number table method,with 48 cases in each group.The conventional treatment group was treated with atorvastatin calcium tablets,while the combined treatment group was treated with Modified Immature Bitter Orange and Rhubarb Decoction combined with acupuncture on the basis of the conventional treatment group.The changes in serum inflammatory factors[including tumor necrosis factor(TNF)-α,interleukin(IL)-6,IL-8,hs-C reactive protein(hs-CRP)],brain dynamics indicators,national institute of health stroke scale(NIHSS)score,modified rankin scale(mRS)score,quality of life(SF-36)score in the two groups before and after treatment and the clinical efficacy were observed.Results:The effective rate of the combined treatment group was 93.75%,which was higher than that of the conventional treat-ment group:77.08%.The difference was statistically significant(P<0.05).After treatment,the serum levels of TNF-α,IL-6,IL-8 and hs-CRP in the combined treatment group were lower than those in the conventional treatment group,and all the differences were statistically significant(P<0.05);Vp and Vm in the combined treatment group were higher than those in the conventional treatment group,and all the differences were statistically significant(P<0.05);The NIHSS score and mRS score in the combined treatment group were lower than those in the conventional treatment group,and all the differences were statistically significant(P<0.05);The scores of quality of life in the combined treatment group were higher than those in the conventional treatment group,and all the differences were statistically significant(P<0.05).Conclusion:Modified Immature Bitter Orange and Rhubarb Decoction combined with collateral-activating acupuncture can improve the clinical efficacy of acute cerebral infarction,reduce the degree of inflammation,promote the recovery of nerve function and improve the quality of life.
作者
贺君
韩冬
HE Jun;HAN Dong(Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu,Henan,China,476000)
出处
《河南中医》
2023年第9期1395-1399,共5页
Henan Traditional Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2023ZY2171)。
关键词
急性期脑梗死
枳实大黄汤
针刺疗法
炎性反应
神经功能
acute cerebral infarction
Immature Bitter Orange and Rhubarb Decoction
acupuncture therapy
inflammatory response
nerve function
