摘要
综述丹红注射液活血化瘀的机制及其与常用抗凝药的相互作用研究进展。丹红注射液主要从抑制血小板聚集和活化、影响内源性和外源性凝血途径中凝血因子的分泌、改善血液流变学指标、抗炎症反应、影响血管内皮细胞等方面起到活血化瘀的作用,并通过对细胞色素P450(CYP450)酶活性的影响提示其与常用抗凝药物联用后潜在的药物相互作用及其机制,可为丹红注射液与其他药物的合理联用提供借鉴。
This paper reviewed the research progress on the mechanism of activating blood and removing stasis of Danhong Injection and its interaction with commonly used anticoagulants.Danhong Injection mainly plays the role of activating blood and removing stasis from the aspects of inhibiting platelet aggregation and activation,affecting the secretion of coagulation factors in endogenous and exogenous coagulation pathways,improving hemorheology indicators,anti-inflammatory reaction,affecting vascular endothelial cells,and so on.Through the effect on the activity of cytochrome P450(CYP450)enzyme,it suggests the potential drug interaction and its mechanism after combined with common anticoagulants.The purpose of this paper is to provide reference for the rational use of Danhong Injection and its combination with other drugs.
作者
刘一枢
丁楠
张天娇
李雪
陈潮
杨铭
LIU Yishu;DING Nan;ZHANG Tianjiao;LI Xue;CHEN Chao;YANG Ming(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《上海中医药杂志》
CSCD
2023年第10期68-75,共8页
Shanghai Journal of Traditional Chinese Medicine
基金
国家“十三五”重大新药创制科技重大专项(2017ZX09304001)
上海市自然科学基金项目(22ZR1462100)
上海中医药大学附属龙华医院第二批科研人才培养计划(RC-2020-02-04)
上海中医药大学附属龙华医院第四批“龙医学者”育苗计划项目(YM2021016)。
关键词
血瘀证
丹红注射液
活血化瘀
抗凝治疗
药物相互作用
研究进展
blood stasis syndrome
Danhong Injection
activating blood and removing stasis
anticoagulation treatment
drug interaction
research progress
