摘要
目的:分析阴道镜联合环形电切除术(LEEP)在子宫颈癌癌前病变患者中的具体效果。方法:选取2020年5月—2022年5月萍乡市妇幼保健院收治的76例子宫颈癌癌前病变患者,按随机数字表法分为对照组和观察组,各38例。对照组单纯行LEEP,观察组行阴道镜联合LEEP。对比两组手术相关指标、炎症因子水平、免疫功能、生活质量和并发症发生率。结果:观察组术中出血量为(20.13±3.20)mL,少于对照组的(34.89±4.67)mL,手术时间为(21.36±2.41)min、住院时间为(4.53±0.89)d,均短于对照组的(37.58±3.53)min、(6.89±1.46)d,并发症发生率为5.26%(2/38),低于对照组的21.05%(8/38),差异均有统计学意义(P<0.05)。术前,两组C反应蛋白(CRP)、白介素-6(IL-6)、CD3^(+)、CD4^(+)、CD8^(+)、健康调查简表(SF-36)各维度评分相比,差异均无统计学意义(P>0.05);术后3 d,观察组CRP、IL-6、CD8^(+)均低于对照组,CD3^(+)、CD4^(+)与SF-36各维度评分均高于对照组,差异均有统计学意义(P<0.05)。结论:阴道镜联合LEEP治疗子宫颈癌癌前病变患者效果显著,可有效减少术中出血量,缩短手术与住院时间,引起的机体炎症反应及免疫抑制更轻,且并发症较少,可加快患者术后恢复,提高生活质量。
Objective:To analyze the effect of colposcopy combined with loop electrosurgical excision procedure(LEEP)in patients with precancerous lesions of cervical cancer.Method:A total of 76 patients with precancerous cervical cancer admitted to Pingxiang Maternity and Child Care from May 2020 to May 2022 were selected and divided into the control group and the observation group according to random number table method,with 38 cases in each group.The control group was received LEEP alone,and the observation group was received colposcopy combined with LEEP.Operation-related indexes,levels of inflammatory factors,immune function,quality of life and complication rate were compared between two groups.Result:The intraoperative blood loss in the observation group was(20.13±3.20)mL,less than(34.89±4.67)mL in the control group,the operation time was(21.36±2.41)min,and the hospital stay was(4.53±0.89)d,both shorter than(37.58±3.53)min and(6.89±1.46)d in the control group,the incidence of complication rate was 5.26%(2/38),lower than 21.05%(8/38)in the control group,the differences were statistically significant(P<0.05).Before operation,there were no significant differences in C reactive protein(CRP),interleukin-6(IL-6),CD3^(+),CD4^(+),CD8^(+),and the all dimensions socres of the short form(SF-36)between two groups(P>0.05);3 days after operation,CRP,IL-6,and CD8^(+)in the observation group were lower than those in the control group,while CD3^(+),CD4^(+)and the socres of SF-36 in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Colposcopy combined with LEEP is effective in the treatment of patients with precancerous lesions of cervical cancer,which can effectively reduce intraoperative blood loss,shorten operation and hospital stay,cause less inflammation and immunosuppression,and fewer complications,accelerate postoperative recovery of patients,improve quality of life.
作者
周婧君
ZHOU Jingjun(Pingxiang Maternity and Child Care,Jiangxi Province,Pingxiang 337000,China)
出处
《中国医学创新》
CAS
2023年第23期14-18,共5页
Medical Innovation of China
关键词
子宫颈癌癌前病变
环形电切除术
阴道镜
炎症因子
生活质量
免疫功能
Precancerous lesions of cervical cancer
Loop electrosurgical excision procedure
Colposcopy
Inflammatory factors
Quality of life
Immune function
