摘要
目的:观察毫火针联合普瑞巴林治疗带状疱疹后遗神经痛(PHN)气滞血瘀证的临床疗效。方法:将84例PHN气滞血瘀证患者按随机数字表法分为对照组、观察组,每组42例。对照组予以普瑞巴林治疗,观察组予以毫火针联合普瑞巴林治疗,2组均治疗14 d。比较2组临床疗效,治疗前后疼痛介质[血清前列腺素E2 (PGE2)、P物质(SP)、5-羟色胺(5-HT)]水平、匹兹堡睡眠质量指数(PSQI)评分、简明健康调查量表(SF-36)评分,以及不良反应发生率。结果:治疗后,观察组临床疗效总有效率95.24%,高于对照组80.95%(P<0.05)。2组血清PGE2、SP、5-HT水平均较治疗前降低(P<0.05),观察组血清PGE2、SP、5-HT水平均低于对照组(P<0.05)。2组PSQI评分均较治疗前降低(P<0.05),SF-36评分均较治疗前升高(P<0.05);观察组PSQI评分低于对照组(P<0.05),SF-36评分高于对照组(P<0.05)。观察组不良反应发生率9.52%,与对照组16.67%比较,差异无统计学意义(P>0.05)。结论:毫火针联合普瑞巴林治疗PHN气滞血瘀证可有效降低疼痛介质水平,缓解疼痛,并能改善患者的睡眠状况及生活质量,安全性好。
Objective:To observe the clinical effect of filiform-fire needle combined with Pregabalin for postherpetic neuralgia(PHN)with qi stagnation and blood stasis syndrome.Methods:A total of 84 cases of PHN patients with qi stagnation and blood stasis syndrome were divided into the control group and the observation group according to the random number table method,with 42 cases in each group.The control group was treated with Pregabalin,and the observation group was treated with filiform-fire needle combined with Pregabalin.Both groups were treated for 14 days.The levels of pain mediators including serum prostaglandin E2(PGE2),substance P(SP)and 5-hydroxytryptamine(5-HT),the scores of Pittsburgh Sleep Quality Index(PSQI)and 36-Item Short Form Health Survey(SF-36)before and after treatment,as well as the incidence of adverse reactions and the clinical effects were compared between the two groups.Results:After treatment,the total effective rate of clinical effect was 95.24%in the observation group,higher than that of 80.95%in the control group(P<0.05).The levels of PGE2,SP and 5-HT in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of PGE2,SP and 5-HT in serum in the observation group were lower than those in the control group(P<0.05).The PSQI scores in the two groups were decreased when compared with those before treatment(P<0.05),and SF-36 scores were increased when compared with those before treatment(P<0.05).The PSQI score in the observation group was lower than that in the control group(P<0.05),and SF-36 score was higher than that in the control group(P<0.05).The incidence of adverse reactions was 9.52%in the observation group and 16.67%in the control group,there being no significance in the difference(P>0.05).Conclusion:Filiform-fire needle combined with Pregabalin for PHN with qi stagnation and blood stasis syndrome can effectively control pain,reduce levels of pain mediators,and improve sleep status and quality of life,with good safety.
作者
童飞
TONG Fei(Anji Traditional Chinese Medicine Hospital,Anji Zhejiang 313300,China)
出处
《新中医》
CAS
2023年第14期141-145,共5页
New Chinese Medicine
关键词
带状疱疹后遗神经痛
气滞血瘀证
毫火针
普瑞巴林
疼痛介质
睡眠
生活质量
Postherpetic neuralgia
Qi stagnation and blood stasis syndrome
Filiform-fire needle
Pregabalin
Pain mediator
Sleep
Quality of life
