摘要
目的探讨2型糖尿病患者葡萄糖目标范围内时间(TIR)与高尿酸血症(HUA)之间的相关性。方法选取2021年6月至2022年5月间就诊于蚌埠医学院第一附属医院的2型糖尿病患者215例为研究对象, 根据血尿酸水平分为HUA组和非HUA组。收集患者一般资料及临床生化指标, 分析其扫描式葡萄糖监测系统(FGMS)72 h的相关指标TIR、平均血糖波动幅度(MAGE)、血糖变异度(CV)、血糖标准差(SDBG)、平均血糖(MBG)与血清尿酸水平之间的相关性, 采用二分类logistic回归分析2型糖尿病合并HUA的影响因素, 并绘制受试者工作特征(ROC)曲线评估其预测价值。结果与非HUA组相比, HUA组的2型糖尿病患者TIR显著降低, 而HbA1C、MAGE、CV、SDBG、MBG则明显升高(P<0.001)。Spearman相关分析结果显示, 血清尿酸水平与TIR之间呈负相关, 而与MAGE、CV、SDBG、MBG呈正相关(P<0.001)。二分类logistic回归分析显示TIR为2型糖尿病合并HUA的独立保护因素。ROC曲线结果显示TIR预测2型糖尿病患者发生HUA的曲线下面积(AUC)为0.856(95%CI 0.803~0.909,P<0.001), 最佳截断值为64.5%、灵敏度为76.8%、特异度为90.3%。结论 2型糖尿病合并HUA的患者TIR明显下降, TIR为2型糖尿病合并HUA的独立保护因素, 且对2型糖尿病患者合并HUA有一定的预测价值。
Objective To investigate the correlation between time within the glucose target range(TIR)and hyperuricemia(HUA)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 215 patients with T2DM in the First Affiliated Hospital of Bengbu Medical College from June 2021 to May 2022 were selected and divided into HUA group and non-HUA group according to serum uric acid level.The clinical characteristics and biochemical indicators of the patients were collected.The association of 72 h glucose monitoring system(FGMS)related indicators TIR,mean blood glucose fluctuation range(MAGE),blood glucose variability(CV),blood glucose standard deviation(SDBG),and mean blood glucose(MBG)with serum uric acid level was analyzed.The influencing factors of T2DM combined with HUA were analyzed with binary logistic regression,and receiver operating characteristic(ROC)curve was drawn to evaluate their predictive values.Results TIR of HUA group was significantly decreased compared with non-HUA group,while HbA1C,MAGE,CV,SDBG,and MBG were increased(P<0.001).Spearman correlation analysis showed that serum uric acid levels were negatively correlated with TIR,but positively correlated with MAGE,CV,SDBG,and MBG(P<0.001).After dichotomous logistic regression analysis,TIR was found to be an independent protective factor for T2DM with HUA.The ROC curve results showed that the area under the curve(AUC)of TIR for predicting HUA in T2DM was 0.856(95%CI 0.803-0.909,P<0.001),with the best cut-off value being 64.5%,the sensitivity being 76.8%,and the specificity being 90.3%.Conclusion TIR in patients with T2DM combined with HUA was significantly decreased.TIR is an independent protective factor for T2DM combined with HUA,and TIR shows a certain predictive value for T2DM combined with HUA.
作者
熊圣喜
张然然
胡红艳
李敏
杨青青
庄兰艮
孙卫华
胡小磊
Xiong Shengxi;Zhang Ranran;Hu Hongyan;Li Min;Yang Qingqing;Zhuang Langen;Sun Weihua;Hu Xiaolei(Department of Endocrinology,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China;Standardized Metabolic Management Center of the First Affiliated Hospital of Bengbu Medical College(MMC),Bengbu 233000,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2023年第7期565-570,共6页
Chinese Journal of Endocrinology and Metabolism
基金
安徽高校自然科学研究项目重大项目(KJ2020ZD53)。
关键词
糖尿病
2型
目标范围内时间
高尿酸血症
相关性
Diabetes mellitus,type 2
Time within the glucose target range
Hyperuricemia
Correlation
