摘要
酰氨醇类(Amphenicols)抗生素是一类广谱抗生素,对革兰阳性及阴性菌都有良好的抑制作用。该类抗生素不仅水溶性差,其毒性、耐药性也逐渐被发现。本文对该类抗生素的作用机制、耐药机制、构效关系、制剂研发、残留检测以及废水处理方面进行了综述,为今后的研究提供参考。
Amphenicol antibiotics were broad-spectrum antibiotic that had good inhibitory activity to G+and G-bacteria.This type of antibiotic not only had poor water solubility,but its toxicity and drug resistance were also gradually being discovered.This article reviews the mechanism of action,resistance mechanism,structureactivity relationship,preparation development,residue detection,and wastewater treatment of amphenicol antibiotics,in order to provide reference for future research.
作者
李准
齐显龙
李剑勇
Li Zhun;Qi Xianlong;Li Jianyong(Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS,Lanzhou 730050,Gansu,China)
出处
《生物医学转化》
2023年第3期57-64,共8页
Biomedical transformation
基金
中国农业科学院科技创新工程项目(25-LZIHPS-02)。
关键词
酰胺醇
制剂研发
残留检测
废水处理
Amphenicol
Preparation development
Residue detection
Wastewater treatment
