摘要
目的:探讨血液透析(HD)和腹膜透析(PD)对终末期糖尿病肾病(ESDN)的疗效。方法:选取2019年5月—2020年12月在肇庆市第一人民医院肾内科透析的ESDN患者100例,按照随机数字表法分为HD组和PD组,各50例。两组均采用常规治疗措施,HD组采用HD,PD组采用PD。比较两组每日尿量、血尿素氮(BUN)、血肌酐(Scr)、尿素清除指数(Kt/V)、总胆固醇(TC)、甘油三酯(TG)、血磷、血钙、血红蛋白(HB)、白蛋白(ALB)、并发症发生率、生活质量、生存率。结果:透析后,PD组每日尿量、Kt/V、HB均高于HD组,BUN、Scr、ALB均低于HD组,差异有统计学意义(P<0.001);透析后,两组TC、TG、血磷、血钙水平比较,差异无统计学意义(P>0.05),PD组并发症总发生率低于HD组,差异有统计学意义(P=0.017);PD组透析后生活质量评分高于HD组,差异有统计学意义(P<0.001);两组透析开始后1、2年的生存率比较,差异无统计学意义(P>0.05)。结论:HD和PD在治疗ESDN方面具有不同的优势。PD对肾功能的改善效果更好,PD患者每日尿量、HB水平、生活质量高且BUN、Scr水平、并发症发生率低,但HD患者ALB水平更高。
Objective:To investigate the effect of hemodialysis(HD)and peritoneal dialysis(PD)on end-stage diabetic nephropa⁃thy(ESDN).Methods:A total of one hundred ESDN patients undergoing dialysis in the Department of Nephrology of Zhaoqing First People's Hospital from May 2019 to December 2020 were selected and divided into HD group and PD group according to ran⁃dom number table method,with fifty patients in each group.Both groups were treated with conventional treatment,HD group was treated with HD and PD group was treated with PD.Daily urine volume,blood urea nitrogen(BUN),blood creatinine(Scr),urea clearance index(Kt/V),total cholesterol(TC),triglyceride(TG),blood phosphorus,blood calcium,hemoglobin(HB),albumin(ALB),complication rate,quality of life and survival rate were compared between the two groups.Results:After dialysis,the daily urine volume,Kt/V,HB in PD group were higher than those in HD group,and BUN,Scr,ALB were lower than those in HD group,with statistical significance(P<0.001);After dialysis,there was no significant difference in the levels of TC,TG,blood phosphorus and blood calcium between the two groups(P>0.05);The total incidence of complications in PD group was lower than that in HD group,the difference was statistically significant(P=0.017);The score of quality of life after dialysis in PD group was higher than that in HD group,the difference was statistically significant(P<0.001);There was no significant difference in the survival rate 1 and 2 years after the start of dialysis between the two groups(P>0.05).Conclusion:HD and PD have different advantages in the treatment of ESDN.PD has a better effect on the improvement of kidney function,PD patients have high daily urine volume,HB level,quality of life and low BUN,Scr level and complication rate,but HD patients have higher ALB level.
作者
黄佳丽
陈衍强
邓丽贞
Huang Jiali;Chen Yanqiang;Deng Lizhen(Department of Nephrology,Zhaoqing First People's Hospital,Zhaoqing 526060,Guangdong Province,China)
出处
《中外医药研究》
2023年第12期18-20,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
基金
2019年肇庆市科技创新指导类项目(编号:201904030743)。
关键词
血液透析
腹膜透析
终末期糖尿病肾病
并发症
生活质量
生存率
Hemodialysis
Peritoneal dialysis
End-stage diabetic nephropathy
Complications
Quality of life
Survival rate
