摘要
目的 比较容积调强放疗以及静态调强放疗对于宫颈癌患者术后的疗效及剂量学。方法 将2020年7月-2022年12月至郑州大学第一附属医院就诊的宫颈癌患者纳入本次研究中,共有58例,随机分为观察组、对照组,每组29例。对照组行静态调强放疗,观察组为容积调强放疗,分析并比较两组患者的剂量学和疗效。结果 两组患者最终疗效比较差异无明显统计学意义(P>0.05);观察组患者的CI、Dmean和D2%显著高于对照组,但是HI和D98%显著低于对照组,两组之间的差异具有统计学意义(P<0.05);观察组生存率高于对照组,两组之间的差异具有统计学意义(P<0.05);对照组出现的不良反应明显高于观察组,两组之间的差异具有一定统计学意义(P<0.05)。结论 对于宫颈癌患者术后的放疗干预而言,容积调强放疗和静态调强放疗均有一定的临床价值,但是容积调强放疗有更好的适形性、更优的剂量分布,可以确保靶区的照射剂量有合适的强度,并有效减少靶区周围组织的总体受量,促使不良反应的发生率进一步降低,值得进行推广和应用。
Objective To compare the efficacy and dosimetry of volumetric intensity modulated radiotherapy and static intensity modulated radiotherapy in patients with cervical cancer after surgery.Methods A total of 58 patients with cer-vical cancer admitted our hospital from July 2020 to December 2022 were included in this study.By means of random drawing,the patients were divided into observation group and control group,with 29 cases in each group.The control group received static intensity modulated radiotherapy and the observation group received volumetric intensity modulated radiotherapy.The dosimetry and efficacy of the two groups were analyzed and compared.Results There was no signifi-cant difference in the final efficacy between the two groups(P>0.05);CI,Dmean and D2%of observation group were significantly higher than those in control group,but HI and D98%were significantly lower than those in control group,the difference between the two groups was statistically significant(P<0.05);The survival rate of the observation group was significantly higher than that of the control group,and the difference between the two groups was statistically signifi-cant(P<0.05);There were more adverse reactions in the control group than in the observation group,and the dffer-ence between the two groups was statistically significant(P<0.05).Conclusion For postoperative radiotherapy inter-vention in patients with cervical cancer,both intensity modulated volumetric radiotherapy and static intensity modulated radiotherapy have certain clinical value.However,with better conformal property and better dose distribution,intensity modulated volumetric radiotherapy can ensure appropriate intensity of radiation dose in the target area and effectively re-duce the overall dose of tissues around the target area,thus further reducing the incidence of adverse reactions.It is worth promoting and applying.
作者
王朝霞
祝宾华
宋方方
WANG Zhao-xia;ZHU Bin-hua;SONG Fang-fang(Department of Radiotherapy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《医药论坛杂志》
2023年第15期60-63,共4页
Journal of Medical Forum
关键词
容积调强放疗
静态调强放疗
宫颈癌
剂量学
Volume intensity modulated radiotherapy
Static intensity modulated radiotherapy
Cervical cancer
Dosimetry
