摘要
目的:观察温阳通络方口服联合外敷治疗寒凝血瘀型子宫内膜异位症的临床疗效。方法:将90例子宫内膜异位症患者随机分为口服组、外敷组、口服+外敷组,每组各30例。3组分别给予温阳通络方口服、温阳通络方外敷、温阳通络方口服+外敷治疗,观察3组治疗后中医证候评分、局部体征评分、疼痛程度(VAS)评分、异位囊肿体积大小、双侧子宫动脉血流阻力指数、血清CA125水平,评价临床综合疗效。结果:各组患者治疗前年龄、病程、既往相关手术次数等基线资料、中医证候评分、局部体征评分、疼痛程度评分、异位囊肿体积、双侧子宫动脉血流阻力指数、血清CA125水平,差异均无统计学意义(P>0.05)。治疗后各组中医证候评分、局部体征评分、疼痛程度评分、异位囊肿体积、双侧子宫动脉血流阻力指数、血清CA125水平均有下降(P<0.05)。治疗后口服+外敷组中医证候总积分、次症积分明显低于其他两组(P<0.05),主症积分明显低于口服组(P<0.05),但与外敷组相比差异无统计学意义(P>0.05);治疗后口服+外敷组疼痛程度评分明显低于其他两组(P<0.05),口服+外敷组中局部体征积分、双侧子宫动脉血流阻力指数、CA125水平明显低于其他两组(P<0.05)。结论:温阳通络方口服联合外敷治疗寒凝血瘀型子宫内膜异位症临床综合疗效明显,能缓解患者痛经程度,改善患者临床症状,提高患者生活质量;另外还能加速患者局部体征的减轻,改善局部微循环状态,下调患者生物学标志物血清CA125的水平。
Objective:To observe the clinical effect of Wenyang Tongluo Decoction combined with external application in the treatment of endometriosis of cold coagulation and blood stasis type.Methods:90 patients with endometriosis were randomly divided into oral group,external application group,oral combined with external application group,with 30 cases in each group.The three groups were treated with Wenyang Tongluo Decoction orally,Wenyang Tongluo Decoction externally,and Wenyang Tongluo Decoction orally combined with externally.After treatment,the TCM syndrome score,local physical sign score,pain degree(VAS)score,ectopic cyst volume,bilateral uterine artery blood flow resistance index,and serum CA125 level were observed to evaluate their clinical comprehensive effect.Results:There were no statistical differences in the baseline data,such as age,course of disease,number of previous relevant operations,TCM syndrome score,local physical sign score,pain degree score,ectopic cyst volume,bilateral uterine artery blood flow resistance index,and serum CA125 level of patients in each group(P>0.05).After treatment,the TCM syndrome score,local physical sign score,pain degree score,ectopic cyst volume,bilateral uterine artery blood flow resistance index and serum CA125 level in all groups decreased(P<0.05).After treatment,the total score of TCM syndromes and the score of secondary symptoms in the oral combined with external application group were significantly lower than those in the other two groups(P<0.05),and the main symptom scores were significantly lower than that in the oral group(P<0.05),but there was no significant difference compared with the external application group(P<0.05).After treatment,the score of pain degree in oral combined with external application group was significantly lower than that of the other two groups(P<0.05),and the score of local physical signs,the resistance index of bilateral uterine artery blood flow and the level of CA125 in oral combined with external application group were significantly lower than those in the other two groups(P<0.05).Conclusion:The treatment method of Wenyang Tongluo Decoction combined with external application has a good clinical comprehensive effect on the treatment of endometriosis of cold coagulation stasis type.It can relieve the degree of dysmenorrhea,improve the clinical symptoms and improve the quality of life of patients.on the other hand,accelerate the reduction of local physical signs and improve local microcirculation.down-regulate the level of serum CA125.
作者
陈新悦
陈宣伊
许小凤
梁国强
Chen Xinyue;Chen Xuanyi;Xu Xiaofeng;Liang Guoqiang(Nanjing University of Chinese Medicine,Nanjing 210000,China;Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215000,China)
出处
《亚太传统医药》
2023年第9期119-124,共6页
Asia-Pacific Traditional Medicine
基金
江苏省苏州市科技发展计划项目(SYSD2020217)
苏州第九批姑苏卫生重点人才项目(GSWS2022107)。
关键词
吴门医派
温阳通络
子宫内膜异位症
内外合治
Wumen School of Chinese Medicine
Wenyang Tongluo Decoction
Endometriosis
Oral Administration Combined with External Application
