摘要
目的采用Meta分析方法综合评价地奥心血康联合钙通道阻滞剂治疗心绞痛患者疗效。方法检索2021年12月31日前发表的试验组为地奥心血康联合钙通道阻滞剂治疗心绞痛的随机对照试验(RCT)研究,对照组为单用钙通道阻滞剂,根据纳入和排除标准筛选文章,并进行数据提取和质量评价,采用RevMan 5.4进行数据分析。结果纳入10篇RCT研究,共计844例患者。地奥心血康联合钙通道阻滞剂在治疗心绞痛总有效率方面高于单用钙通道阻滞剂,有统计学意义(RR=1.25,95%CI:1.17~1.34,P<0.00001);试验组和对照组在发作次数方面两者具有统计学意义(SMD=-7.65,95%CI:-10.17~-5.13,P<0.00001),在持续时间上两者也具有统计学意义的差异(SMD=-9.62,95%CI:-12.76~-6.49,P<0.00001)。结论相较于单用钙通道阻滞剂,联合应用地奥心血康对改善心绞痛的相关结局指标更具优势,但本纳入研究的文献质量普遍较低,期待未来更多高质量RCT支撑本研究结论。
Objective To review comprehensively the curative effect of Di'ao Xinxuekang(XXK)Capsule combined with calcium channel blocker(CCB)for patients with angina pectoris(AP)by applying a Meta-analysis.Methods The randomized controlled trials(RCT)on AP treatment with XXK Capsule combined with CCB(test group)and with only CCB(control group)were retrieved before Dec.31,2021.RCT were screened according to inclusion and exclusion criteria,data was extracted,quality was reviewed,and data was analyzed by using RevMan 5.4 software.Results There were totally 10 RCT included involved 844 cases.The total effective rate in AP treatment was higher in test group than that in control group(RR=1.25,95%CI:1.17~1.34,P<0.00001).The difference in AP seizure times had statistical significance between test group and control group(SMD=-7.65,95%CI:-10.17~-5.13,P<0.00001),and difference in AP seizure duration also had statistical significance between 2 groups(SMD=-9.62,95%CI:-12.76~-6.49,P<0.00001).Conclusion Compared with CCB alone,CCB combined with XXK Capsule has an advantage in improving outcome indexes related to AP.But the quality of included RCT is lower,and more RCT with higher quality are expected to support the conclusion in this study.
作者
李梦媛
曹兆流
鲍柏屹
Li Mengyuan;Cao Zhaoliu;Bao Baiyi(Department of Pharmacy,Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;不详)
出处
《中国循证心血管医学杂志》
2023年第7期777-780,792,共5页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
江苏省药学会恒瑞医院药学基金(H202005)。
关键词
地奥心血康
钙通道阻滞剂
心绞痛
META分析
Di'ao Xinxuekang Capsule
Calcium channel blocker
Angina pectoris
Meta-analysis
