摘要
目的探讨艾滋病相关机会性感染病原菌的分布特点并分析其耐药性。方法此研究选取天津市第二人民医院收治的艾滋病患者为研究对象,观察患者2019年1月-2020年12月期间多重耐药菌分布情况、观察并探讨患者入住ICU时间与多重耐药菌感染情况的相关性,探讨该研究选取标本的来源情况、耐药情况。结果共培养出阳性结果3264株,其中多重耐药菌1254株,研究中共分离大肠埃希菌276株,对头孢吡的耐药率为66.30%,对亚胺培南的耐药率为4.71%,对哌拉西林的耐药率为17.39%;共分离铜绿假单胞菌142株,对头孢吡的耐药率为64.79%,对亚胺培南的耐药率为63.38%,对哌拉西林的耐药率为52.82%;共分肺炎克雷伯菌231株,对头孢吡的耐药率为49.78%,对亚胺培南的耐药率为20.35%,对哌拉西林的耐药率为9.52%;共分离金黄色葡萄球菌23株,对苯唑西林的耐药率为73.91%,对红霉素的耐药率为65.22%,对利奈唑胺的耐药率为4.35%。结论艾滋病患者感染病原菌分布较广,耐药率较高,为避免长期应用广谱抗菌药物而造成细菌耐药,需加强对艾滋病机会性感染病原菌耐药性的动态监测。
Objective To investigate the distribution and drug resistance of HIV-associated Opportunistic infection pathogens in patients with AIDS.Method To observe the distribution of multi-drug resistant bacteria in patients from January 2019 to December 2020,and to explore the correlation between the time of ICU stay and multi-drug resistant bacteria infection,to investigate the source and drug resistance of the selected samples.Results A total of 3264 strains were positive,of which 1254 strains were multi-drug resistant.276 strains of Escherichia coli were isolated.The resistance rate to cefpixime and imipenem was 66.30% and 4.71%respectively,the resistant rate to peracillin was 17.39%.142 strains of Pseudomonas aeruginosa were isolated.The resistant rate to cefepime,imipenem and peracillin were 64.79%,63.38%and 52.82%,respectively,a total of 231 strains of klebsiella pneumoniae were isolated.The resistant rates to cefepime,imipenem and peracillin were 49.78%,20.35%and 9.52%,respectively,the drug resistance rates to oxacillin,erythromycin and Linezolid were 73.91%,65.22%and 4.35%.Conclusions Respectively,high drug resistance to avoid the long-term use of broad-spectrum antibiotics caused by bacterial resistance,it is necessary to strengthen the dynamic monitoring of drug resistance of Opportunistic infection pathogens of AIDS.
作者
刘婧婕
Liu Jingjie(Tianjin Second People's Hospital,Tianjin 300110,China)
出处
《首都食品与医药》
2023年第18期42-45,共4页
Capital Food Medicine
关键词
艾滋病
病原菌分布
耐药性分析
AIDS
distribution of pathogens
drug resistance analysis
