摘要
目的探讨食管癌患者血清癌胚抗原(CEA)、糖类抗原72-4(CA72-4)、细胞角蛋白19片段(CYFRA21-1)等肿瘤标志物的表达水平及其与临床病理特征的关系,为食管癌的临床诊疗及病情评估提供参考依据。方法回顾性分析2019年1月至2021年12月山西医科大学第二医院收治的80例食管癌患者作为观察组,另选择同期健康体检志愿者80例作为对照组进行研究。采用化学发光免疫法检测患者血清CEA、CA72-4、CYFRA21-1等肿瘤标志物表达水平。比较两组血清CEA、CA72-4、CYFRA21-1表达水平及阳性率,分析血清CEA、CA72-4、CYFRA21-1表达水平与临床病理特征的关系。结果观察组血清CEA、CA72-4、CYFRA21-1表达水平均高于对照组(P均<0.05),血清CEA、CA72-4、CYFRA21-1均高于对照组(P均<0.05);病理分期Ⅲ~Ⅳ期、组织学中/高分化程度、浸润外膜及有淋巴结转移患者血清CEA、CA72-4、CYFRA21-1水平均高于病理分期Ⅰ~Ⅱ期、组织学低分化程度、浸润肌层及无淋巴结转移的患者(P均<0.05),性别、年龄及病理类间差异均无统计学意义(P均>0.05);Pearson相关分析结果显示,血清CEA表达水平与CA72-4、CYFRA21-1中/高表达水平无相关性(r=0.115、0.231,P均>0.05),血清CA72-4表达水平与CYFRA21-1表达水平无相关性(r=0.103,P>0.05)。结论CEA、CA72-4、CYFRA21-1在食管癌患者血清中呈高表达,与食管癌病理分期、组织学分化程度、浸润深度及淋巴结转移等病理特征有关。
Objective To investigate the expression levels of serum carcinoembryonic antigen(CEA),carbohydrate antigen 72-4(CA72-4),cytokeratin 19 fragment(CYFRA21-1)and other tumor markers in patients with esophageal cancer and their relationship with clinicopathological characteristics,so as to provide a reference for clinical diagnosis and treatment of esophageal cancer and disease evaluation.Methods The clinical data of 80 patients with esophageal cancer treated in the Second Hospital of Shanxi Medical University from January 2019 to December 2021 were analyzed as observation group retrospectively,and 80 healthy volunteers in the same period were selected for control group.The expression levels of serum tumor markers such as CEA,CA72-4 and CYFRA21-1 were detected by chemiluminescence immunoassay.The expression levels and positive rates of serum CEA,CA72-4 and CYFRA21-1 were compared between the two groups,and the relationship between the expression levels of serum CEA,CA72-4 and CYFRA21-1 and clinicopathological features was analyzed.Results The expression levels of serum CEA,CA72-4 and CYFRA21-1 in the observation group were higher than those in the control group(P all<0.05),and the positive rates of serum CEA,CA72-4 and CYFRA21-1 were higher than those in the control group(P all<0.05).The serum of CEA,CA72-4 and CYFRA21-1 in patients with pathological stageⅢ-Ⅳ,high and medium histological differentiation,infiltration of the outer membrane,and lymph node metastasis were higher than those in patients with pathological stageⅠ-Ⅱ,histological low differentiation,infiltration of the muscular layer and no lymph node metastasis(P all<0.05),there were no significant difference in gender,age and pathological types(P all>0.05).Pearson analysis showed that there was no correlation between the expression levels of serum CEA and CA72-4、CYFRA21-1(r=0.115,0.231,P all>0.05),while serum CA72-4 expression levels were not correlated with CYFRA21-1 expression levels(r=0.103,P>0.05).Conclusion CEA,CA72-4 and CYFRA21-1 are highly expressed in the serum of patients with esophageal cancer,which is related to the pathological stage,histological differentiation,depth of invasion and lymph node metastasis of esophageal cancer.
作者
孟俊杰
武晋荣
程冬明
郭光伟
MENG Junjie;WU Jinrong;CHENG Dongming;GUO Guangwei(Department of Cardiothoracic Surgery,the Second Hospital of Shanxi Medical University,Taiyuan 030013,China;Department of Oncology,the Second Hospital of Shanxi Medical University,Taiyuan 030013,China)
出处
《宁夏医科大学学报》
2023年第8期809-813,共5页
Journal of Ningxia Medical University
关键词
癌胚抗原
糖类抗原72-4
细胞角蛋白19片段
食管癌
病理特征
相关性
carcinoembryonic antigen
carbohydrate antigen 72-4
cytokeratin 19 fragment
esophageal cancer
pathological features
relevance
