摘要
动脉粥样硬化是多种心脑血管系统疾病的重要病理基础,血小板活化和低密度脂蛋白浓度增加是其最重要的病理生理机制,以他汀类为代表的降脂药物在治疗动脉粥样硬化方面具有显著疗效,但仍存在缺陷和弊端。本文以血小板上的低密度脂蛋白结合位点、血小板是氧化低密度脂蛋白作用靶点以及活化的血小板和氧化低密度脂蛋白在动脉粥样硬化中的作用为切入点总结当前研究证据,阐明这些互作关系在动脉粥样硬化发生发展中的临床意义,系统分析互作机制作为动脉粥样硬化诊疗靶点的利弊,旨在为动脉粥样硬化的防治提供新思路。
Atherosclerosis is an important pathological basis of many cardiovascular and cerebrovascular diseases.Platelet activation and the increase of low-density lipoprotein concentration are the most important pathophysiological mechanisms.Lipid lowering drugs represented by statins have significant efficacy in treating atherosclerosis,but there are still defects and drawbacks.In this paper,we summarize the current research evidence based on the low density lipoprotein binding sites on platelets,platelets as the target of oxidized low density lipoprotein and the role of activated platelets and oxidized low density lipoprotein in atherosclerosis,clarify the clinical significance of these interactions in the development of atherosclerosis,and systematically analyze the advantages and disadvantages of interaction mechanisms as the target of atherosclerosis diagnosis and treatment,so as to provide a new strategy for the prevention and treatment of atherosclerosis.
作者
马明仁
王菲
马凌
MA Mingren;WANG Fei;MA Ling(Department of Cardiology,the 940th Hospital of Joint Logistics Support Force of Chinese PLA,Lanzhou 730050,Gansu Province,China)
出处
《解放军医学院学报》
CAS
北大核心
2023年第7期817-820,共4页
Academic Journal of Chinese PLA Medical School
基金
甘肃省自然科学基金资助项目(21JR1RA181)
解放军联勤保障部队第940医院院内资助项目(2021yxky080,2021yxky031)。
关键词
低密度脂蛋白
低密度脂蛋白胆固醇
氧化低密度脂蛋白
血小板
动脉粥样硬化
low-density lipoprotein
low-density lipoprotein cholesterol
oxidized ox-low-density lipoprotein
platelets
athero-sclerosis
