摘要
肺癌是最常见的恶性肿瘤之一,目前临床上主要采用手术、放疗和化疗等方式治疗,但抗肿瘤药物的长期使用易出现耐药。中药单体雷公藤甲素对肺癌具有良好的治疗作用,其抗肺癌机制包括诱导细胞凋亡、抑制肺癌细胞侵袭和迁移、联合用药、逆转耐药和协同抗肿瘤等。本文就雷公藤甲素抗肺癌的作用机制及应用进展进行综述,以期为雷公藤甲素抗肺癌的进一步深入研究提供参考。
Lung cancer is one of the most common malignant tumors.Currently,surgery,radiotherapy and chemotherapy are mainly used in clinical treatment.However,long-term use of antitumor drugs will easily cause drug resistance.In recent years,it was found that triptolide has a good therapeutic effect on lung cancer,and its anti-lung cancer mechanisms include inducing cell apoptosis,inhibiting lung cancer cell invasion and migration,reversing drug resistance and collaborating in defeating the tumor.In this paper,the mechanism of triptolide against lung cancer and its application progress were reviewed,in order to provide reference for further research.
作者
薛锐
谭亲友
XUE Rui;TAN Qinyou(School of Pharmacy,Guilin Medical University,Guilin 541199;Dept.of Clinical Pharmacy and Clinical Pharmacology,Affiliated Hospital of Guilin Medical University,Guilin 541001,China)
出处
《华夏医学》
CAS
2023年第4期166-173,共8页
Acta Medicinae Sinica
基金
国家自然科学基金项目(82160765)。
关键词
雷公藤甲素
肺癌
作用机制
纳米药物
triptolide
lung cancer
mechanism of action
nanometer drug
