摘要
粘细菌(myxobacteria)是一类具有多细胞群体行为特征的药源微生物类群。粘细菌能通过次级代谢产生大量结构新颖并具有生物活性的小分子天然产物,还能分泌种类、功能丰富多样的酶类。这些生物活性产物使粘细菌不仅具有重要的研究价值,还有广泛的应用前景。然而,资源挖掘困难、次级代谢产物得率低等制约因素的存在严重阻碍了粘细菌的研究和应用。本文主要对粘细菌的生物学特征、生物活性产物、生物合成调控及在医疗、农业和食品上的应用进行归纳总结,并结合已有成果对粘细菌研究存在的问题提出可能的对策和展望,为今后粘细菌的深入研究和资源开发利用提供参考。
Myxobacteria are a group of medical microorganisms showing complex multicellular behaviors.On one hand,they produce a variety of natural bioactive compounds with novel structures through secondary metabolism.On the other hand,they can secrete diverse functional enzymes.Therefore,myxobacteria are valuable for basic research and applications.However,the research on them has been impeded by the difficulties in resource mining and the low yield of secondary metabolites.This review introduces myxobacteria in terms of the biological characteristics,bioactive products,regulation on biosynthesis and applications in medicine,agriculture and food industry.Based on available results,the problems in the research on myxobacteria and the possible countermeasures are presented.This review is expected to provide reference for the in-depth research and the resource development and utilization of myxobacteria.
作者
翟辰欣
吕莹
汪绍杰
樊博
王泽建
吴杰群
梁剑光
ZHAI Chenxin;LÜYing;WANG Shaojie;FAN Bo;WANG Zejian;WU Jiequn;LIANG Jianguang(School of Pharmacy and School of Biological and Food Engineering,Changzhou University,Changzhou 213164,Jiangsu,China;School of Biotechnology,East China University of Science and Technology,Shanghai 200237,China;College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China)
出处
《微生物学通报》
CAS
CSCD
北大核心
2023年第9期4237-4259,共23页
Microbiology China
基金
国家重点研发计划(2021YFC2101000)
国家自然科学基金(32071471)
江苏省研究生科研与实践创新计划(SJCX23_1456)。
关键词
粘细菌
生物活性产物
生物合成
应用
myxobacteria
bioactive products
biosynthesis
applications
