摘要
脂肪干细胞(ADSCs)是起源于中胚层的成体干细胞,存在于脂肪组织基质中,增殖能力强,具有多向分化潜能。外泌体(exosomes)是由细胞内多泡体与细胞膜融合后,释放到细胞外基质中的膜性囊泡,具有尺寸较小、可穿过生物细胞屏障的特点,可介导细胞间的信息交流。目前从ADSCs中分离出外泌体的技术已经相当成熟,并且在各医学领域中得到了广泛应用。本文将对脂肪干细胞外泌体(ADSCs-exo)在皮肤创面和组织修复中的研究进展进行综述。
Adipose stem cells(ADSCs)are adult stem cells that originate from the mesoderm and exist in the adipose tissue matrix.They have strong proliferative ability and multi-directional differentiation potential.Exosomes are membranous vesicles released into the extracellular matrix after the fusion of intracellular vesicles and cell membranes.They have the characteristics of small size and can pass through biological cell barriers,and can mediate information exchange between cells.At present,the technology of isolating exosomes from ADSCs is quite mature and has been widely applied in various medical fields.This article will review the research progress of adipose stem cell exosomes(ADSCsexo)in skin wounds and tissue repair.
作者
陈翔宇
童小斐
胡杨
周建大
李萍
Chen Xiangyu;Tong Xiaofei;Hu Yang;Zhou Jianda;Li Ping(Department of Plastic Surgery,the Third Xiangya Hospital of Central South University,Changsha 410013,China)
出处
《中国医师杂志》
CAS
2023年第9期1427-1430,共4页
Journal of Chinese Physician
关键词
脂肪干细胞
外泌体
皮肤创面
组织修复
Adipose-derived stem cell
Exosomes
Skin trauma
Tissue repair
