摘要
目的分析非酒精性脂肪肝病(NAFLD)治疗研究现状、热点及发展趋势,为后续研究提供参考。方法检索Web of Science数据库,收集建库起至2022年12月31日治疗NAFLD的相关文献,利用CiteSpace 6.1.R6构建可视化图谱,对作者、国家及机构进行合作网络分析,同时进行关键词共现、聚类和突现分析,分析其研究现状和热点。结果共纳入文献3882篇,发文量呈逐年增长的趋势。发文量排名前3位的国家为中国、美国和日本。发文量最多的作者是美国的Sanyal(37篇),发文量最多的机构是加州大学圣地亚哥分校(75篇)。国外联系紧密的研究团队以大型随机对照试验(RCT)为主,对包括药物、生活方式等多种干预措施治疗NAFLD的有效性和安全性进行了评估;而国内研究以有效药用成分治疗NAFLD的基础研究为主,且以中医药为特色,相关的高质量大型RCT较少。关键词分析结果显示,各国研究以调控肝脏氧化应激和炎症、改善全身糖脂代谢平衡为主,除降糖药物外,作用于多种综合调控体内代谢稳态靶点的药物进入临床试验阶段,具有巨大的治疗潜力。结论NAFLD治疗研究热度持续增长,并以调控全身代谢稳态靶点和相关药物为研究导向。作为研究主力,我国应加强与国际的交流,把握基础研究的趋势,重视临床研究的开展,不断挖掘传统中药的治疗潜力。
OBJECTIVE To analyze the current status,hotspots and development trends of research on the treatment of non-alcoholic fatty liver disease(NAFLD),providing reference for subsequent research.METHODS Searching the Web of Science database,the literature related to the treatment of NAFLD from the establishment of the database to December 31,2022 were collected.CiteSpace 6.1.R6 was used to construct a visual atlas,perform collaborative network analysis on authors,countries and institutions,and conduct keyword co-occurrence,clustering and emergence analysis to explore its research status and hotspots.RESULTS A total of 3882 articles were included,and the number of publications had been increasing year by year.The top three countries in terms of publication volume were China,the United States,and Japan.The author with the highest volume of publications was Sanyal from the United States(37 articles),while the institution with the highest volume of publications was the University of California,San Diego(75 articles).A closely connected research team abroad mainly conducted large-scale randomized controlled trials(RCT)to evaluate the effectiveness and safety of various interventions,including medication and lifestyle,in treating NAFLD.However,domestic researches mainly focused on basic researches about the treatment of NAFLD with effective medicinal ingredients,and were characterized by traditional Chinese medicine.There were relatively few high-quality large-scale RCT studies related to it.Keyword analysis showed that researches in various countries mainly focused on regulating liver oxidative stress and inflammation,improving the overall balance of glucose and lipid metabolism.Except for hypoglycemic drugs,drugs that act on various comprehensive metabolic homeostasis targets in the body had entered clinical research,and had enormous therapeutic potential.CONCLUSIONS The research on NAFLD treatment continues to grow in popularity and tends to research targets and drugs for regulating systemic metabolic homeostasis.As the main force of research,China should strengthen communication with the international community,grasp the trends and directions of basic research,attach importance to clinical research,and continuously tap the therapeutic potential of traditional Chinese medicine.
作者
朱宝强
张明名
杨诗语
胡佳强
李文渊
龙恩武
ZHU Baoqiang;ZHANG Mingming;YANG Shiyu;HU Jiaqiang;LI Wenyuan;LONG Enwu(School of Pharmacy,Southwest Medical University,Sichuan Luzhou 646000,China;Department of Pharmacy,Sichuan Academy of Medical Science&Sichuan Provincial People’s Hospital/Affiliated Hospital of University of Electronic Science and Technology of China,Chengdu 610072,China;School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China)
出处
《中国药房》
CAS
北大核心
2023年第18期2243-2249,共7页
China Pharmacy
基金
中国研究型医院学会药物评价专委会《临床重点药品的使用监测和评价研究专项课题》(No.Y2022FH-YWPJ01-201)
个体化药物治疗四川省重点实验室开放和自拟课题(No.2021YB06)。
