摘要
免疫疗法被广泛认为是许多恶性肿瘤的重要治疗方法,但由于耐药性和免疫逃逸等原因,大多数患者易于出现复发。最新研究表明,肿瘤微环境中的免疫细胞和免疫宏环境相互影响,并进而影响肿瘤的治疗。中医学认为,肿瘤的形成源于人体正气虚衰和邪实凝聚,这也是肿瘤免疫宏微环境的核心概念。正被邪克是肿瘤免疫环境的宏观态势;邪气停聚是肿瘤免疫环境的病势核心;正虚和邪聚互为因果,对机体免疫造成负面影响。正邪失衡成为贯穿和影响肿瘤免疫宏环境的内在因素和重要基础。
Immunotherapy is widely regarded as an important treatment for many malignant tumors,but most patients are prone to relapse due to drug resistance and immune escape.The latest research shows that immune cells in tumor microenvironment and immune macroenvironment interact with each other,and then affect the treatment of tumor.Traditional Chinese medicine believes that the formation of tumors stems from the decline of healthy Qi and the coagulation of pathogenic factors,which is also the core concept of tumor immune macro-micro environment.It is the macroscopic trend of tumor immune environment to be overcome by evil;The stagnation of pathogenic factors is the core of tumor immune environment;Deficiency of Zheng Qi and accumulation of pathogen are mutually causal,which has a negative impact on the body's immunity.The imbalance between good and evil has become an internal factor and an important foundation that runs through and affects the macro-environment of tumor immunity.
作者
陈明骏
仝战旗
CHEN Mingjun;TONG Zhanqi(The Second Medical Center of Chinese PLA General Hospital/National Clinical Medical Research Center for Geriatric Diseases,Beijing China 100853)
出处
《中医学报》
CAS
2023年第10期2089-2094,共6页
Acta Chinese Medicine
基金
军队保健专项科研课题项目(20BJZ31)
首都卫生发展科研专项项目(首发2022-4-5032)。
关键词
“正虚邪聚”
肿瘤免疫宏环境
肿瘤免疫微环境
免疫疗法
"Zheng Qi deficiency and pathogen accumulation"
macroenvironment of tumor immunity
tumor immune microenvironment
immunotherapy
