摘要
宫颈持续感染高危型人乳头瘤病毒(HR-HPV)是宫颈上皮内瘤变(CIN)及宫颈癌的主要危险因素。中医学认为宫颈HR-HPV感染多属湿热,宫颈癌属本虚标实之证,正气虚弱、冲任失调为本,湿热瘀毒凝结为标。西医学认为病毒负荷量增加、免疫功能紊乱、阴道局部微环境改变均可能增加HR-HPV持续感染及宫颈病变进展风险。HR-HPV持续感染是宫颈癌进展过程中的重要因素,临床以湿热证、痰湿证最为常见,清热祛湿是基本的治疗原则,可通过降低机体病毒负荷量、改善机体免疫状态等途径,促进HR-HPV转阴、改善临床症状,进而预防CIN和宫颈癌的发生发展。
Persistent infection of high-risk human papillomavirus(HR-HPV)in the cervix is the main risk factor for cervical intraepithelial neoplasia(CIN)and cervical cancer.Traditional Chinese medicine(TCM)believes that cervical HR-HPV infection mostly falls in the category of damp-heat,while cervical cancer is a syndrome of deficiency as the root and excess as the branch,which indicates weakness of healthy qi and disharmony of the chong and ren mai as the root cause,and congealing of toxin from dampness and heat stasis as the branch.Western medicine believes that increased viral load,immune dysfunction,and changes in local vaginal microenvironment may contribute to HR-HPV persistent infection and consequently increase the risk of developing cervical cancer.Persistent infection of HRHPV,an important factor in the progression of cervical cancer,is commonly characterized by the patterns of damp-heat and phlegm-damp.Accordingly,the method of clearing heat and dispelling dampness is adopted as the basic treatment principle.By reducing the body’s viral load and improving immunity,it can accelerate the clearing of HPV infections,improve the symptoms,and prevent the occurrence and development of CIN and cervical cancer.
作者
王楚伊赢
曹莹
陈璐
李晓斌
王文萍
WANG Chuyiying;CAO Ying;CHEN Lu;LI Xiaobin;WANG Wenping(Liaoning University of Traditional Chinese Medicine,Shenyang 110847;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine)
出处
《现代中医临床》
2023年第4期84-87,共4页
Modern Chinese Clinical Medicine
基金
国家重点研发计划项目(No.2018YFC1311600)
辽宁省中医大师(辽宁省名中医)传承工作室建设项目(辽中医药综合字[2021]32号)
辽宁省“兴辽英才计划”项目(No.XLYC1802008)。
关键词
宫颈癌
人乳头状瘤病毒
清热祛湿
治疗机制
cervical carcinoma
human papillomavirus
clearing heat and dispelling dampness
therapeutic mechanism
