摘要
能量平衡失调被认为是一个影响人类疾病的重要驱动因素,单磷酸腺苷活化的蛋白激酶(AMP-activated protein kinase,AMPK)作为一种重要的能量传感器,在维持能量稳态中的核心作用使其成为预防和治疗疾病的一个关键靶点。铁死亡作为一种新型细胞死亡方式,与多种疾病的病理生理过程有关,而AMPK相关信号通路又是调控铁死亡的重要途径,明确AMPK具体通过何种通路诱导或抑制铁死亡,将为未来疾病治疗提供新思路,为新药研究提供新靶点。该文通过整理国内外相关文献,挖掘了AMPK调控铁死亡的相关信号通路,并对AMPK调控铁死亡相关信号通路在疾病中的应用进行了综述,旨在为后期研究提供参考。
Energy imbalance is considered an important driver of human diseases.As an important energy sensor,AMPK plays a central role in maintaining energy homeostasis,making it a key target for disease prevention and treatment.As a new type of cell death,ferroptosis is related to the pathophysiological process of many diseases,and AMPK-related signaling pathway is an important way to regulate iron death.Understanding which pathway AMPK induces or inhibits ferroptosis will provide new ideas for the treatment of diseases in the future and provide new targets for new drug research.In this paper,we review the related literatures and explore the signaling pathways of AMPK regulating ferroptosis,with a brief description of the application of AMPK-mediated ferroptosis related signaling pathways in diseases,hoping to provide reference for later research.
作者
王锋
秦文秀
王琪
邓震亭
WANG Feng;QIN Wen-xiu;WANG Qi;DENG Zhen-ting(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第10期1801-1805,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 82104995)
天津市教委科研计划项目(No 2022ZD045)。
