摘要
胎盘作为维持正常妊娠的基础,是母胎交流的重要媒介。胎盘组织处于纤维化、缺氧、慢性炎症和血液供应不足等状态可导致流产、子痫前期、妊娠期糖尿病和早产等妊娠并发症的发生,严重影响女性健康及胎儿结局。线粒体作为能量代谢的枢纽,其动力学、生物合成、氧化磷酸化等过程异常会引起胎盘组织炎症因子水平增加,氧化和抗氧化失衡,造成胎盘功能损伤,从而促进各种妊娠并发症的发生发展。综述目前关于胎盘线粒体功能障碍对多种妊娠并发症的影响,探讨其中的潜在机制。
As the foundation for maintaining normal pregnancy and an important medium for maternal-fetal communication,the placenta can cause various pregnancy complications such as miscarriage,preeclampsia,gestational diabetes,and premature birth when it is in a state of fibrosis,hypoxia,chronic inflammation,insufficient blood supply,and other conditions.These complications can seriously affect women′s health and fetal outcomes.Mitochondria,as the hub of energy metabolism,can increase the level of inflammatory factors in placental tissue,disrupt the balance between oxidation and antioxidation,and resulting in placental functional damage when their dynamics,biosynthesis,oxidative phosphorylation,and other processes are abnormal,thereby promoting the occurrence and development of various pregnancy complications.This article reviews the current research on the impact of placental mitochondrial dysfunction on a variety of pregnancy complications and to explore the potential mechanisms involved.
作者
计恩婷
许雅绚
张春仁
胡敏(审校)
马红霞
JI En-ting;XU Ya-xuan;ZHANG Chun-ren;HU Min;MA Hong-xia(The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510000,China)
出处
《国际妇产科学杂志》
CAS
2023年第5期497-501,共5页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(8197150075,82104915)。
关键词
胎盘
线粒体
流产
自然
先兆子痫
糖尿病
妊娠
Placenta
Mitochondria
Abortion,spontaneous
Pre-eclampsia
Diabetes,gestational
