摘要
目的分析探讨精神分裂症症状痊愈的相关预测因子。方法选取2018年7月至2019年3月泉州市第三医院收治的303例首发精神分裂症患者作为研究对象,采用氨磺必利治疗。采用阳性和阴性症状条目6项指标(PANSS-6)、席汉残疾量表(SDS)评估患者症状痊愈情况和功能损害情况,分析影响首发精神分裂症痊愈的危险因素。采用ROC曲线评价影响首发精神分裂症痊愈的独立危险因素对精神分裂症痊愈的预测价值。结果采用PANSS-6评分将其分为治愈组和非治愈组,其中A标准痊愈244例,非痊愈59例,单因素分析结果提示,两组的病程、用药剂量、SDS评分和改善率比较,差异有统计学意义(P<0.05);B标准痊愈258例,非痊愈45例,单因素分析结果提示,两组的病程、SDS评分和改善率比较,差异有统计学意义(P<0.05)。多因素分析结果提示,性别(β=0.69,OR=1.99)是使用标准A时影响痊愈的危险因素(P<0.05),SDS(β=-0.08,OR=0.92)是使用标准A时影响痊愈的保护因素(P<0.05);SDS(β=-0.11,OR=0.89)是使用标准B时影响痊愈的保护因素(P<0.05)。ROC曲线结果显示,SDS评分对精神分裂症患者使用A、B标准预测痊愈的AUC分别为0.685、0.729(P<0.05)。结论SDS评分可以作为精神分裂症患者痊愈指标的一个独立预测因子。
Objective To analyze and explore the related predictors of recovery in schizophrenia.Methods A total of 303 patients with first-episode schizophrenia admitted to Quanzhou Third Hospital from July 2018 to March 2019 were selected as the study subjects and treated with Amsulpride.Symptom recovery and functional impairment were evaluated by positive and negative symptom item 6(PANSS-6)and Sheehan disability scale(SDS),and the risk factors affecting recovery of first-episode schizophrenia were analyzed.The predictive value of the above independent risk factors for recovery was evaluated by ROC curves.Results According to PANSS-6 scores,they were divided into recovery group and non-recovery group.According to standard A,there were 244 recovery cases and 59 non-recovery cases.The results of univariate analysis showed that there were significant differences in disease course,medication dosage,SDS score and improvement rate between the two groups(P<0.05).According to standard B,there were 258 recovery cases and 45 non-recovery cases.The results of univariate analysis showed that there were significant differences in disease course,SDS score and improvement rate between the two groups(P<0.05).The results of multivariate analysis showed that gender(β=0.69,OR=1.99)was a risk factor of recovery under standard A(P<0.05),while SDS(β=-0.08,OR=0.92)was a protective factor(P<0.05).SDS(β=-0.11,OR=0.89)was a protective factor of recovery under standard B(P<0.05).The results of ROC curves analysis showed that AUC values of SDS score for predicting recovery of schizophrenia patients under standard A and B were 0.685 and 0.729,respectively(P<0.05).Conclusion SDS score can be applied as an independent predictor of recovery in patients with schizophrenia.
作者
林义川
郑金炽
柯龙婷
潘洪润
LIN Yichuan;ZHENG Jinchi;KE Longting;PAN Hongrun(Department of Psychiatry,Quanzhou Third Hospital,Fujian Province,Quanzhou362000,China;Department of Psychiatry,Jinjiang Third Hospital,Fujian Province,Jinjiang362000,China)
出处
《中国当代医药》
CAS
2023年第28期79-82,共4页
China Modern Medicine
基金
福建省泉州市科技计划项目(2021N003S)。
