摘要
京尼平苷是中药栀子的主要活性成分,属环烯醚萜苷类化合物,京尼平是其体内代谢产物。阐述京尼平、京尼平苷的抗肿瘤作用及其机制,总结相关中药方剂治疗肿瘤或改善化疗后不良反应的临床应用,以期为研发新型抗肿瘤药物提供依据和思路。显示京尼平和京尼平苷对肺癌、胃癌、乳腺癌、肝癌等多种癌症具有抗肿瘤效应。京尼平的抗肿瘤作用包括诱导肿瘤细胞凋亡、阻滞肿瘤细胞周期、抑制肿瘤细胞侵袭、特异性抑制解偶联蛋白(UCP2)等;京尼平苷的抗肿瘤作用包括抗血管生成、抑制RNA、抑制拓扑异构酶I等。两者均可辅助化疗药物,减轻化疗后不良反应,但作用机制不同。
Geniposide is the main active ingredient of Chinese medicine Zhizi(Fructus Gardeniae),which belonging to the iridoid glycoside class,and genipin is its metabolite in vivo.This article elaborated the anti-tumor effects and mechanisms of genipin and geniposide,summarized the clinical applications of relevant traditional Chinese medicine formulas in treating tumors or improving adverse reactions after chemotherapy,in order to provide a basis and ideas for the development of new anti-tumor drugs.It showed that genipin and geniposide have anti-tumor effects on lung cancer,gastric cancer,breast cancer,liver cancer and other cancers.The antitumor effects of genipin include inducing tumor cell apoptosis,blocking tumor cell cycle,inhibiting tumor cell invasion,specifically inhibiting UCP2,and etc.The antitumor effects of geniposide include anti-angiogenesis,inhibition of RNA,inhibition of topoisomerase I,and etc.Both of them can be adjuvant chemotherapy drugs and alleviate adverse reactions after chemotherapy,but the mechanisms of action are different.
作者
姬俊
邵露
陈静
JI Jun;SHAO Lu;CHEN Jing(Qingdao Institute for Food and Drug Control/NMPA Key Laboratory for Quality Reasearch and Evaluation of Traditional Marine Chinese Medicine,Qingdao Shandong 266073,China;Qingdao Hospital of Traditiononal Chinese Medicine/Qingdao Hiser Hospital,Qingdao Shandong 266000,China)
出处
《中医药导报》
2023年第9期75-81,共7页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
青岛市中医药科技项目(2021-zyyq05)。
关键词
京尼平
京尼平苷
抗肿瘤
栀子
作用机制
综述
genipin
geniposide
antitumor
Frctus Gardeniae
mechanism
summarize
