摘要
目的:探讨早期糖尿病肾病(Diabetes nephropathy,DN)外周血分泌型卷曲相关蛋白1(secreted curl associated protein 1,SFRP1)、血脂素(serum adiponectin,APN)、纤溶酶原激活物抑制物-1(plasminogen activator inhibitor-1,PAI-1)水平变化情况及临床检测意义。方法:回顾性分析襄城县人民医院2019年6月—2021年2月收治的115例糖尿病患者的临床资料,分为糖尿病组54例和DN组61例,另选择同期体检健康者45例为正常对照组。分别采集3组受试者晨起空腹外周静脉血,检测血清SFRP1、APN、PAI-1、空腹血糖(FPG)、糖化血红蛋白(HbAle)、空腹胰岛素、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、甘油三酯(TG)及肌酐水平,计算胰岛素抵抗指数(HOMA-IR);分析血清SFRP1、APN、PAI-1水平与早期DN患者临床相关指标的相关性。结果:糖尿病组和DN组受试者的FPG、HbA1c、空腹胰岛素、HOMA-IR、TC、LDL-C、TG、肌酐水平均高于正常对照组,HDL-C水平低于正常对照组,差异有统计学意义(F=228.01、162.12、257.10、464.95、10.01、21.91、10.35、145.00、481.63,P<0.05)。糖尿病组受试者血清SFRP1、APN、PAI-1水平与正常对照组,DN组受试者血清SFRP1、PAI-1水平高于糖尿病组,而血清APN水平低于糖尿病组及正常对照组,差异有统计学意义(F=398.82、406.70、28.32,P<0.05)。DN患者血清SFRP1、APN、PAI-1水平与FPG、HbA1c、空腹胰岛素、HOMA-IR、TC、LDL-C、TG、肌酐呈正相关,与HDL-C呈负相关(P<0.05)。结论:早期DN患者血清SFRP1、PAI-1水平升高及APN水平降低,可能参与了疾病的发生及发展过程。
Objective:To investigate the changes in the levels of secreted curl associated protein 1(SFRP1),serum adiponectin(APN)and plasminogen activator inhibitor-1(PAI-1)in peripheral blood of early diabetic nephropathy(DN)and their clinical sig⁃nificance.Methods:The clinical data of 115 diabetic patients admitted to the hospital from June 2019 to February 2021 were ret⁃rospectively analyzed and divided into 54 cases in the diabetic group and 61 cases in the DN group,and another 45 cases in the same period of physical examination were selected as the normal control group.Morning fasting peripheral venous blood was collected from three groups of subjects,and serum SFRP1,APN,PAI-1,fasting blood glucose(FPG),glycated hemoglobin(HbAle),fasting insulin,total cholesterol(TC),high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),triglyceride(TG)and creatinine levels were measured,and insulin resistance index(HOMA-IR)was calculated.The correlation of serum SFRP1,APN,and PAI-1 levels with clinically relevant indices in patients with early DN was analyzed.Results:The levels of FPG,HbA1c,fasting insulin,HOMA-IR,TC,LDL-C,TG,and creatinine were higher in the diabetic and DN groups than in the normal control group,and HDL-C levels were lower than in the normal control group,with statistically significant differences(F=228.01,162.12,257.10,464.95,10.01,21.91,10.35145.00,481.63,P<0.05).The serum SFRP1,APN and PAI-1 levels were higher in the diabetic group than in the normal control group,and the serum SFRP1 and PAI-1 levels were higher in the subjects in the DN group than in the diabetic group,while the serum APN levels were lower than in the diabetic and normal control groups,with statistically sig⁃nificant differences(F=398.82,406.70,28.32,P<0.05).Serum SFRP1,APN,and PAI-1 levels were positively correlated with FPG,HbA1c,fasting insulin,HOMA-IR,TC,LDL-C,TG,and creatinine,and negatively correlated with HDL-C in DN patients(P<0.05).Conclusion:Elevated serum SFRP1 and PAI-1 levels and reduced APN levels in patients with early DN may be in⁃volved in the onset and progression of the disease.
作者
张凯
Zhang Kai(Department of Laboratory,Xiangcheng County People’s Hospital,Xuchang,Henan,461700,China)
出处
《黑龙江医学》
2023年第20期2487-2489,共3页
Heilongjiang Medical Journal
