摘要
为挖掘广藿香(Pogostemon cablin)内生真菌活性代谢产物,采用多种柱色谱分离方法从广藿香内生真菌Ogataea sp.RW-S10的次级代谢产物中分离得到7个化合物,根据波谱数据分别鉴定为ogataearin(1)、phenylalaninol(2)、对羟基苯乙酮(3)、bis(dethio)bis(methylsulfanyl)gliotoxin(4)、N-苯乙基乙酰胺(5)、lumichrome(6)和dehydroxypaxilline(7),其中化合物1为新化合物。化合物1具有α-葡萄糖苷酶抑制活性,其IC50值为39.38μmol/L。
In order to obtain bioactive metabolites from Pogostemon cablin endophytic fungus,seven secondary metabolites were isolated and purified from the patchouli endophytic fungus Ogataea sp.RW-S10 by various chromatographic column techniques.Based on spectral data,their structures were identified as ogataearin(1),phenylalaninol(2),parahydroxyacet-ophenone(3),bis(dethio)bis(methylsulfanyl)gliotoxin(4),N-phenylethyl acetamide(5),lumichrome(6),and dehydroxypaxilline(7).Compound 1 was a new compound and showedα-glucosidase inhibitory activity with IC50 value of 39.38μmol/L.
作者
阮武
郭教岑
马青云
杨理
谢晴宜
吴友根
赵友兴
RUAN Wu;GUO Jiaocen;MA Qingyun;YANG Li;XIE Qingyi;WU Yougen;ZHAO Youxing(College of Horticulture,Hainan University,Haikou 570228,China;Haikou Key Laboratory for Research and Utilization of Tropical Natural Products,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Science,Haikou 571101,China;Hainan Academy of Tropical Agricultural Resource,Chinese Academy of Tropical Agricultural Science,Haikou 571101,China)
出处
《热带亚热带植物学报》
CAS
CSCD
北大核心
2023年第5期741-746,共6页
Journal of Tropical and Subtropical Botany
基金
海南省重点研发计划项目(ZDYF2021SHFZ075)
财政部和农业农村部国家现代农业产业技术体系专项(CARS-21)
农业农村部财政专项项目(NFZX2021)
中国热带农业科学院基本科研业务费专项(1630052022030)资助。
关键词
广藿香
内生真菌
次级代谢产物
抗菌活性
Pogostemon cablin
Endophytic fungi
Secondary metabolite
Antimicrobial activity
