摘要
The more than three decades of research in nucleic acid nanotechnology has led to the thrilling progress in rationally designed structures and artificial molecular devices with programmable functions and various applications.Nucleic acid–based aggregates feature precise molecular recognition and sequence programmability,versatility,as well as marked biocompatibility,providing promising candidates for biomedical applications.In this minireview,we summarize the recent,successful efforts to construct and employ nucleic acid–based aggregates for biomedical applications,including drug delivery,bioimaging,biosensing,cell analysis,and combined cancer therapy.We also discuss the remaining challenges and opportunities in the field.
基金
National Natural Science Foundation of China,Grant/Award Numbers:22025201,32071389,31700871,51761145044,21721002
National Basic Research Program of China,Grant/Award Numbers:2016YFA0201601,2018YFA0208900
Beijing Municipal Science&TechnologyCommission,Grant/Award Number:Z191100004819008
KeyResearch Program of Frontier Sciences,CAS,Grant/Award Number:QYZDBSSW-SLH029
Strategic Priority Research Program of Chinese Academy of Sciences,Grant/Award Number:XDB36000000
CAS Interdisciplinary Innovation Team,and the K.C.Wong Education Foundation,Grant/Award Number:GJTD-2018-03
Youth Innovation Promotion Association,CAS。
