摘要
目的观察独活寄生汤联合自体带骨膜髂骨移植治疗HeppleⅤ期距骨骨软骨损伤(OLTs)的临床疗效。方法将100例OLTs患者按照随机数字表法分为对照组和治疗组,每组50例。对照组行自体带骨膜髂骨移植手术治疗,治疗组在对照组治疗基础上加用独活寄生汤。比较2组治疗前后炎症因子白细胞介素6(IL-6)、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)和超敏C反应蛋白(hs-CRP)水平,疼痛视觉模拟评分(VAS),踝关节活动度(ROM)。结果治疗后,2组IL-6、IL-1β、TNF-α和hs-CRP水平均较本组治疗前明显降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗后,2组疼痛VAS均较本组治疗前降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗后,2组踝关节ROM较本组治疗前无明显变化(P>0.05),且2组组间比较差异也无统计学意义(P>0.05)。结论独活寄生汤联合自体带骨膜髂骨移植治疗HeppleⅤ期距骨骨软骨损伤疗效确切,可明显减轻患者炎症反应、疼痛程度。
Objective To investigate the clinical effect of Duhuo Jisheng Decoction combined with autogenous periosteum iliac bone graft in treating Hepple stageⅤosteochondral lesions of the talus(OLTs).Methods A total of 100 patients with OLTs were enrolled by random number table method,with 50 cases in each group.All patients were treated with autogenous periosteum iliac bone graft,and the patients of the treatment group were addtationlly treated with Duhuo Jisheng Decoction.The levels of inflammatory factors including interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factorα(TNF-α)and high-sensitivity C-reactive protein(hs-CRP),visual analog scale(VAS)pain,ankle range of motion(ROM)were included as comparisos between the two groups before and after treatment.Results After treatment,the levels of IL-6,IL-1β,TNF-αand hs-CRP in the both groups were significantly lower than those before treatment(P<0.05),and which in the treatment group were significantly lower than the control group(P<0.05).The scores of VAS pain in both groups were significantly lower than those before treatment(P<0.05),and the decrease in the treatment group was more common(P<0.05).The ankle ROM in both groups was comparable to before treatment(P>0.05),and with no statistically significant difference between groups(P>0.05).Conclusion For paients with OLTs,Duhuo Jisheng Decoction combined with autogenous periosteum iliac bone graft has a definite curative effect,which can significantly reduce the inflammatory response and pain degree.
作者
刘核达
黄飞
刘林
李鹏伟
李明
李森田
LIU Heda;HUANG Fei;LIU Lin;LI Pengwei;LI Ming;LI Sentian(First Department of Foot and Ankle,Cangzhou Hospital of Integrated TCM-WM·Hebei,Cangzhou,Hebei 061000)
出处
《河北中医》
2023年第10期1601-1604,共4页
Hebei Journal of Traditional Chinese Medicine
基金
河北省中医药管理局2020年度中医药类科研计划项目(编号:2020508)
沧州市科学技术局2021年沧州市科技计划自筹项目(编号:213106116)。
