摘要
建立电感耦合等离子体-质谱法同时测定蒲地蓝消炎片中铅、镉、砷、汞、铜5种元素的分析方法,并对其进行安全性评价及健康风险评估。各元素标准曲线相关系数均大于0.999,检出限为0.001~0.008 mg/kg,加标回收率为89.6%~104.6%,样品测定结果的相对标准偏差为0.8%~3.8%(n=6)。多元统计结果显示,不同厂家的产品重金属残留量存在一定的差异性。安全性评价结果显示,平均单项污染指数顺序为砷>铜>镉>铅>汞,内梅罗综合污染指数为0.23~0.82,多数样品处于安全级。以每日最大可耐受量作为评估标准时,各厂家蒲地蓝消炎片中重金属残留对人体健康无显著影响,但以标靶危害系数作为评估标准时,各厂家砷和重金属总量存在一定的健康风险。该研究可为蒲地蓝消炎片质量控制和安全性评价提供参考依据,并为蒲地蓝消炎片安全性限量标准的制定提供数据支撑。
The contents of lead,cadmium,arsenic,mercury,and copper in Pudilan Xiaoyan Tablets were determined simultaneously by inductively coupled plasma mass spectrometry(ICP-MS),and then the safety and health risk of the elements were evaluated.The correlation coefficients of the standard curves of all elements were greater than 0.999,the detection limits were 0.001-0.008 mg/kg,the recoveries were 89.6%-104.6%,and the relative standard deviations of the test results were 0.8%-3.8%(n=6).Multivariate statistical results showed that there were some differences in the contents of heavy metasl among the products from different manufacturers.Safety evaluation results showed that the average single pollution index was As>Cu>Cd>Pb>Hg,and the Nemerow comprehensive pollution index was 0.23-0.82,most of the samples were in safety level.When maximum daily tolerance was used as the evaluation standard,the heavy metal residues in Pudilan Xiaoyan tablets of each manufacturers had no significant impact on human health,but when target hazard quotients(THQ)was used as the evaluation standard,there were certain health risks from As and the total amount of heavy metals.This study can provide a reference for the quality control,safety evaluation,and data support for the formulation of the safety limit standard of Pudilan Xiaoyan Tablets.
作者
刘婷
石婧
陆羚子
张梦奇
周勇
王琼芬
LIU Ting;SHI Jing;LU Lingzi;ZHANG Mengqi;ZHOU Yong;WANG Qiongfen(Zhoushan Institute for Food and Drug Control,Zhoushan 316000,China)
出处
《化学分析计量》
CAS
2023年第9期10-16,共7页
Chemical Analysis And Meterage
基金
浙江省基础公益研究计划项目(LGF19H280009)。
关键词
蒲地蓝消炎片
综合策略法
重金属及有害元素
化学计量学
安全性评价
健康风险评估
Pudilan Xiaoyan Tablets
comprehensive strategy
heavy metals and harmful elements
chemometrics
safety evaluation
health risk assessment
