摘要
提高母畜的繁殖性能,挖掘其繁殖潜力是提高养殖场生产效率和效益的重要措施之一。雌性哺乳动物繁殖过程的调控是通过下丘脑-垂体-卵巢轴(Hypothalamus-Pituitarary-Ovarial Axis,HPO)实现的,其中卵泡刺激素(Follicle Stimulating Hormone,FSH)发挥重要作用。在HPO轴中,FSH对卵泡发育和排卵的效应主要通过正负反馈调控机制来实现。作为一种糖蛋白激素,FSH不能直接穿透细胞膜,需要与细胞膜表面G蛋白偶联受体(FSHR)结合,激活下游一系列级联信号通路,作用于靶细胞。另外,FSH的调控作用不仅局限于转录水平,一些具有调控作用的非编码RNA(如miRNA,lncRNA)也可在转录后水平调控FSH的合成与分泌,维持雌性哺乳动物体内各生殖激素的平衡,保证繁殖过程的正常进行。
Improving reproductive performances,deeply exploring their reproductive potentials is one of the important measures in animal production.The reproductive process of females is regulated through hypothalamus-pituitarary-ovarial axis(HPO axis),among which follicle-stimulating hormone(FSH)plays essential role.As a kind of glycoprotein hormone,FSH can’t go through cell membrane,and need to recognize GPCR(G protein couple receptor)to activate a series of signal cascade,and work on target cells.The regulation of FSH is not only limited in transcriptional level,but also on posttranscriptional level,some of non-coding RNA(miRNA,lncRNA)can also work on FSH,and maintain the balance of reproductive hormones and normal reproductive processes.
作者
蒙萌
谢学渊
王坤
牛晓艳
MENG Meng;XIE Xueyuan;WANG Kun;NIU Xiaoyan(College of Animal Science,Shanxi Agricultural University,Shanxi Taigu 030801,China)
出处
《中国畜牧杂志》
CAS
CSCD
北大核心
2023年第10期93-102,共10页
Chinese Journal of Animal Science
基金
山西省基础研发计划项目(202103021224174)
山西省重点实验室开放课题基金项目(K272107080)。
关键词
卵泡刺激素
雌性哺乳动物
繁殖
调控
Follicle stimulating hormone(FSH)
Female mammals
Reproduction
Regulation
