摘要
目的分析新鲜单卵裂胚与单囊胚移植周期妊娠结局及其影响因素。方法回顾性分析广西壮族自治区妇幼保健院生殖中心2002年10月至2020年10月行卵裂期与囊胚期单胚胎移植(SET)共5543个周期的患者临床资料。根据胚胎移植时期分为第3天卵裂胚组(D3组,1229例)和第5天囊胚组(D5组,4314例)。比较两组临床资料及妊娠结局,采用二元logistic回归分析SET周期妊娠结局的影响因素。结果SET周期临床妊娠率为48.13%(2668/5543),活产率为39.49%(2189/5543),多胎率为2.89%(77/2668)。二元logistic回归分析结果显示,年龄和胚胎发育时期是SET临床妊娠结局和活产结局的共同影响因素(P<0.05)。分层分析结果显示,年龄≤30岁且优胚数>3枚的D3组和D5组的临床妊娠率(54.55%vs 54.76%)、活产率(49.09%vs 47.21%)比较差异无统计学意义(P>0.05)。结论新鲜周期选择单卵裂胚和单囊胚移植均可获得较好的临床妊娠率和活产率。选择合适人群,单卵裂胚移植可获得与单囊胚移植周期相似的临床妊娠率和活产率。
Objective To analyze the pregnancy outcomes and influencing factors of fresh single cleavage and single blastocyst transfer cycle.Methods The clinical data of patients who underwent a total of 5543 cycles of cleavage stage and blastocyst stage single embryo transfer(SET)from October 2002 to October 2020 in the Reproductive Center of the Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region were retrospectively analyzed.According to different embryo transfer periods,they were divided into day 3 cleavage embryo group(D3 group,1229 cases)and day 5 blastocyst group(D5 group,4314 cases).The clinical data and pregnancy outcomes were compared between the two groups,and the influencing factors of pregnancy outcomes in SET cycle were analyzed by binary logistic regression.Results The clinical pregnancy rate in the SET cycle was 48.13%(2668/5543),and the live birth rate was 39.49%(2189/5543)and the multiple birth rate was 2.89%(77/2668).The results of binary logistic regression analysis showed that age and embryonic development period were the co-influencing factors of SET clinical pregnancy outcomes and live birth outcomes(P<0.05).The results of stratified analysis showed that there were no significant differences in the clinical pregnancy rate(54.55%vs 54.76%)and the live birth rate(49.09%vs 47.21%)between the D3 group and the D5 group,both with age≤30 years and the number of good quality embryos>3(P>0.05).Conclusion The selection of single cleavage stage and single blastocyst stage transfer in fresh cycle can obtain better clinical pregnancy rate and live birth rate.The clinical pregnancy rate and live birth rate of single cleavage stage transfer can be similar to those of single blastocyst stage transfer in a suitable population.
作者
黄映琴
黄冬梅
黄玲
殷妹
文茜茜
梁琳
张波
HUANG Ying-qin;HUANG Dong-mei;HUANG Ling(Reproductive Center,the Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region,Nanning 530002,China)
出处
《中国临床新医学》
2023年第9期951-957,共7页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广西自然科学基金面上项目(编号:2013GXNSFAA019258)
国家重点研发计划项目(编号:2016YFC1000205)
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(编号:Z20170778)。
关键词
单胚胎移植
卵裂胚
囊胚
妊娠结局
Single embryo transfer(SET)
Cleavage stage embryo
Blastocyst
Pregnancy outcome
