摘要
目的探究拉贝洛尔联合硫酸镁治疗对妊娠期高血压综合征(妊高征)患者血压水平、血管内皮功能、炎性因子、血液流变学指标、不良妊娠结局及不良反应的影响。方法选取80例妊高征患者,根据抽签法分为对照组与研究组,每组40例。对照组使用硫酸镁治疗,研究组使用拉贝洛尔联合硫酸镁治疗。比较两组患者临床效果。结果治疗后,研究组患者的收缩压、舒张压水平、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及C-反应蛋白(CRP)水平、全血高切黏度、全血低切黏度及血浆黏度指标均低于对照组,差异具有统计学意义(P<0.05)。研究组患者的血管内皮素-1指标低于对照组,一氧化氮指标高于对照组,差异具有统计学意义(P<0.05)。研究组的不良妊娠结局发生率5.00%明显低于对照组的25.00%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论妊高征患者实施拉贝洛尔联合硫酸镁对病情具有改善作用,维持良好的妊娠结局,值得临床推广。
Objective To explore the effects of labetalol combined with magnesium sulfate on blood pressure,vascular endothelial function,inflammatory factors,hemorheological indexes,adverse pregnancy outcomes and adverse reactions in patients with pregnancy-induced hypertension syndrome(PIH).Methods 80 patients with pregnan-induced hypertension were divided into control group and study group according to the drawing method,with 40 cases in each group.The control group was treated with magnesium sulfate,and the study group was treated with labetalol combined with magnesium sulfate.The clinical effect of the two groups was compared.Results After treatment,the systolic blood pressure,diastolic blood pressure,serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)levels,whole blood high tangential viscosity,whole blood low tangential viscosity and plasma viscosity indexes of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The endothelin-1 index of the study group was lower than that of the control group,and the NO index was higher than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcome in the study group(5.00%)was significantly lower than that in the control group(25.00%),and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In patients with pregnancy-induced hypertension,labetalol combined with magnesium sulfate can improve the condition and maintain good pregnancy outcome,which is worthy of clinical promotion.
作者
李建爱
马爱丽
LiJianai;Ma Aili(Obstetrics and Gynecology,Pingshun Maternal and Child Health Care and Family Planning Service Center,Changzhi 047400,China)
出处
《实用妇科内分泌电子杂志》
2023年第16期93-95,108,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
妊娠期高血压综合征
拉贝洛尔
硫酸镁
不良反应
血压
Pregnancy-induced hypertension syndrome
Labetalol
Magnesium sulfate
Adverse reactions
Blood pressure
