摘要
目的:基于数据挖掘法研究中药治疗输卵管炎性不孕(SI)的用药规律,为临床处方用药提供参考。方法:通过检索2013年1月1日至2022年12月31日中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊(VIP)等数据库中有关“中药”“输卵管炎性不孕”的文献,利用Excel 2021将中药种类进行分类及频数统计分析,并利用SPSS 25.0、SPSS Modeler 18.0等统计学软件对高频中药进行聚类分析、关联规则分析,最后利用Cytoscape 3.9.1软件构建药物关联网络图。结果:搜集到治疗SI的各种有效中药方剂147首,用药以活血化瘀药为主,如赤芍、当归、丹参等;四气以寒性为主,五味以苦、辛为主,归经以肝、脾经为主;高频药物聚类分析得到6个药物组合、关联规则分析得到15个药物组合;药物关联网络提示关联性最强的中药组合为“三棱-莪术”。结论:SI主要病机为瘀血阻滞、胞脉不通,治疗以活血化瘀通络为主,注意兼顾他证。
Objective:To investigate the medication rule of traditional Chinese medicine(TCM)in the treatment of salpingitis infertility(SI)based on data mining techniques.Methods:The databases such as CNKI,WANFANG Data,and VIP were searched for articles on“traditional Chinese medicine”and“salpingitis infertility”published from January 1 st,2013 to December 31 st,2022.Excel 2021 was used to perform the classification of TCM drugs and the statistical analysis of frequency;SPSS 25.0 and SPSS Modeler 18.0 were used to perform cluster analysis and association rule analysis for high-frequency TCM drugs;Cytoscape 3.9.1 was used to construct a drug association network.Results:A total of 147 valid TCM prescriptions were obtained for the treatment of SI,and blood-activating and stasis-resolving drugs were mainly used,such as Radix Paeoniae Rubra,Angelica sinensis,and Salvia miltiorrhiza.Most drugs were cold in nature and had a bitter or pungent taste,and they mainly entered the liver and spleen meridians.The cluster analysis of high-frequency drugs obtained 6 drug combinations,and the association rule analysis obtained 15 drug combinations.The drug association network showed that the TCM drug combination of Rhizoma Sparganii-Curcuma zedoaria had the strongest association.Conclusion:The main pathogenesis of SI is blood stasis and vascular obstruction of uterine collaterals,and activating blood,resolving stasis,and dredging collaterals are the main treatment methods,with consideration of other syndromes.
作者
孟颖
代函芮
赵薇婷
徐佳
匡继林
MENG Ying;DAI Hanrui;ZHAO Weiting;XU Jia;KUANG Jilin(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005,Hunan,China)
出处
《湖南中医杂志》
2023年第8期36-41,共6页
Hunan Journal of Traditional Chinese Medicine
基金
湖南省自然科学基金项目(2022JJ70108)
湖南省中医药科研计划项目(2020011)。
关键词
输卵管炎性不孕
中药
数据挖掘
用药规律
salpingitis infertility
traditional Chinese medicine
data mining
medication rule
