摘要
目的观察加味犀角地黄汤联合司库奇尤单抗治疗寻常型银屑病血热证的临床疗效。方法将90例患者随机分为3组,每组30例。3组均予卡泊三醇软膏外用,中药组予加味犀角地黄汤治疗;西药组予司库奇尤单抗治疗;联合组予加味犀角地黄汤联合司库奇尤单抗治疗。观察各组治疗前后银屑病面积和严重程度指数(PASI)评分、涉及体表受累面积(BSA)评分、皮肤病生活质量指数(DLQI)评分变化及不良反应发生情况。结果治疗后,西药组及联合组总有效率高于中药组(P<0.05)。联合组PASI评分及DLQI评分低于另外2组(P<0.05)。治疗期间各组患者未出现严重不良反应。结论加味犀角地黄汤联合司库奇尤单抗治疗寻常型银屑病血热证疗效显著,安全性良好。
Objective To observe the clinical curative effect and safety of modified Xijiao Dihuang decoction combined with secukinumab in treating moderate to severe psoriasis vulgaris with blood-heat syndrome.Methods 90 patients were randomly divided into 3 groups,with 30 cases in each group.All the 3 groups were treated with capotriol ointment for external use.The Chinese medicine group was treated with modified Xijiao Dihuang decoction.The Western medicine group was treated with secuchiumab.The combined group was treated with modified Xijiao Dihuang decoction combined with secuchiumab.Psoriasis area and severity index(PASI)score,skin surface involved area(BSA)score,skin quality of life index(DLQI)score and the occurrence of adverse reactions were observed before and after treatment in each group.Results After treatment,the total effective rate of the western medicine group and the combined group was higher than that of the Chinese medicine group(P<0.05).The PASI scores and DLQI scores of the combined group were lower than those of the other 2 groups(P<0.05).There were no serious adverse reactions during treatment.Conclusion Modified Xijiao Dihuang decoction combined with secukinumab in treating moderate to severe psoriasis vulgaris with blood-heat syndrome is effective and safe.
作者
巫星玥
石全
贺琪
WU Xingyue;SHI Quan;HE Qi(Clinical College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Hubei Province,Wuhan 430060,China;Dermatology Department,Hubei Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan 430060,China)
出处
《光明中医》
2023年第18期3623-3626,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
中国中医科学院基础所自主选题项目(No.YZ-1743)
湖北省卫生健康委中医药科研项目(No.ZY2019Q019)
湖北省中医院/湖北中医药大学附属医院院内课题(No.2021YJKT-6)。
关键词
白疕
寻常型银屑病
犀角地黄汤
司库奇尤单抗
中西医结合疗法
psoriasis
psoriasis vulgaris
Xijiao Dihuang decoction
secukinumab
therapy of integrated traditional Chinese and Western medicine
