摘要
目的高血压病是一种心脑血管疾病,全球发病率为20%,每年患病人数呈直线上升趋势,且患病率及致残率明显增高,严重危害人类健康。研究该病发病机制及治疗方法需要理想的动物模型。方法基于高血压病的中西医临床病证特点,检索高血压病及其动物模型相关文献,对现有的高血压病动物模型优缺点及其临床症状吻合度进行分析探讨。结果发现中西医临床病证特点吻合度较高的模型为自发性高血压动物模型、两肾一夹法动物模型、高盐高脂饮食模型、高嘌呤高糖致高血压模型,能够模拟出阴虚阳亢、肝火上炎、痰湿中阻等常见中医证候。结论具备中西医临床病证特点的高血压病动物模型更符合临床实际应用。建立病证结合,既有西医临床病理指标,又有中医证候特点的动物模型,是中医实验动物模型的一种新的发展方向。
Objective Hypertension is a cardiovascular disease,with a global prevalence of 20%.The number of patients is increasing every year,and the prevalence and disability rates have significantly increased.It is a serious threat to human health.An ideal animal model is needed for the study of pathogenesis and treatment of this disease.Methods In this paper,the literature on hypertension and its animal models were searched based on the clinical evidence of hypertension in Chinese and western medicine,and then the advantages and disadvantages of the existing animal models of hypertension and their consistency of clinical symptoms were analyzed.Results It was found that the models of hypertension combining Chinese syndrome and western disease with higher degree of coincidence were the spontaneous hypertension animal model,the two-kidney and one-clip animal model,the high-salt and high-fat diet model,and the high-purine and high-sugar hypertension model,which could simulate the common Chinese medical symptoms such as hyperactive yang due to yin deficiency,up-flamming of liver fire and phlegm-damp blocking the middle energizer.Conclusion The models of hypertension combining Chinese clinical syndrome and western disease are the ideal models for hypertension research,not only because these models meet the diagnostic criteria of hypertension,but also because they simulate well the relevant syndromes of traditional Chinese medicine(TCM).It is a new direction for development of animal models in TCM experiments.
作者
罗娜
范文涛
王倩
LUO Na;FAN Wentao;WANG Qian(Shaanxi University of Chinese Medicine,Xianyang 712046 Shaanxi,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2023年第10期1419-1425,共7页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金项目(82274332)。
关键词
高血压病
动物模型
中西医病证结合
诊断标准
hypertension
animal model
combination of Chinese syndrome and Western disease
diagnostic criteria
