摘要
目的:探究间苯三酚对宫腔内人工授精妊娠结局及患者血清促红细胞生成素产生肝细胞受体(Eph)A5、可溶性血管内皮细胞生长因子受体-1(SFlt-1)表达的影响。方法:选取2019年5月-2022年2月本院生殖医学中心收治的120例接受宫腔内人工授精术中超声发现子宫内膜蠕动快的患者,按知情同意原则分为对照组(n=60,采用宫腔内人工授精)和观察组(n=60,在对照组基础上给予间苯三酚)。比较两组妊娠结局、血清EphA5、SFlt-1、促黄体生成素(LH)、雌二醇(E_(2))水平、卵泡成熟个数、子宫内膜厚度及不良反应。结果:治疗后,观察组临床妊娠率(23.3%)、异位妊娠率、生化妊娠率(15.0%)和28周以上持续妊娠率(18.3%)均高于对照组(8.3%、3.0%、5.0%),流产率、多胎妊娠率低于对照组(P<0.05)。两组血清SFlt-1、E_(2)水平均较治疗前降低、EphA5、LH水平较治疗前升高,且观察组上述指标变化幅度大于对照组,不良反应总发生率观察组(5.0%)低于对照组(20.0%)(均P<0.05)。结论:间苯三酚可改善宫腔内人工授精妊娠结局,可提高患者血清EphA5、LH水平,降低血清SFlt-1、E_(2)水平,用药安全可靠。
Objective:To explore the impacts of phloroglucinol for treating women with intrauterine insemination ontheir pregnancy outcomes and the expression levels of serum erythropoietin produces hepatocyte receptor(Ephr)A5and SFlt-1.Methods:120 women with fast endometrium peristalsis found by ultrasound during intrauterine artificialinsemination were selected and were divided into study group and control group(60 cases in each group)according tothe principle of informed consent from May 2019 to February 2022.60 women in the study group received phlorogluci-nol treatment additionally.The pregnancy outcomes,the levels of serum EphrA5,SFlt-l,LH,and E_(2),the number ofmature follicles,the endometrial thickness,and the adverse reaction of the women were compared between the twogroups.Results:The clinical pregnancy rate(23.3%),the ectopic pregnancy rate,the biochemical pregnancy rate(15.0%),and the rate of pregnancy over 28 gestational weeks(18.3%)of the women in the study group were signifi-cantly higher than those(8.3%,3.0%,and 5.0%)of the women in the control group.The rates of abortion and themultiple pregnancyof the women in the studygroup were significantly lower than those of the women in controlgroup(P<0.05).The serum SFlt-l and E_(2) levels of the women in both groups after treatment had decreased significantly,the SFlt-1 and LH levels of the women in both groups after treatment had increased significantly,and the changes degree of which of the women in the observation group were significantly more than those of the women in the controlgroup.The total incidence of adverse reactions(5.0%)of the women in the observation group was significantly lowerthan that(20.0%)of the women in the control group(all P<0.05).Conclusion:Phloroglucinol for treating womenwith intrauterine insemination can improve their serum EphA5 and LH levels,and can reduce the serum SFltl and E_(2) levels,withsafetyand reliability.
作者
李永乐
张丽
杨光
季清云
申小静
王婷婷
LI Yongle;ZHANG Li;YANG Guang;JI Qingyun;SHEN Xiaojing;WANG Tingting(HenanInstituteof Reproductive Health Scienceand Technology/HenanReproductiveand Maternity Hospital,Zhengzhou,HenanProvince,450002;Henan Provincial Third Hospital)
出处
《中国计划生育学杂志》
2023年第10期2394-2397,共4页
Chinese Journal of Family Planning
