摘要
目的:探讨2型糖尿病病人中血清25羟维生素D(25-OH-VD)水平与甲状腺功能及甲状腺自身抗体之间的关系。方法:选取2型糖尿病病人181例,其中维生素D缺乏组101例,维生素D不足组62例,维生素D充足组18例。分析3组中25-OH-VD水平与总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、抗甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)以及空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血脂等指标的相关性。结果:维生素D缺乏组与维生素D充足组的甲状腺功能水平差异均无统计学意义(P>0.05),但维生素D缺乏组TgAb、TPOAb、胆固醇(TC)、三酰甘油(TG)、HbA1c高于维生素D充足组(P<0.05)。相关性分析显示25-OH-VD与HbA1c、TT3、TgAb、TPOAb、TG、TC、性别均呈负相关(P<0.05)。logistic回归结果发现,性别及25-OH-VD是TPOAb阳性的影响因素。结论:维生素D缺乏在2型糖尿病中很常见,维生素D的缺乏程度与HbA1c水平相关,且高25-OH-VD水平是TPOAb阳性的保护因素。
Objective:To investigate the relationship between serum 25-hydroxyvitamin D(25-OH-VD)level and thyroid function and thyroid autoantibodies in patients with type 2 diabetes mellitus.Methods:A total of 181 patients with type 2 diabetes mellitus were selected,including 101 patients with vitamin D deficiency,62 patients with vitamin D insufficiency,and 18 patients with vitamin D sufficiency.The correlations between 25-OH-VD and total triiodothyronine(TT3),total thyroxine(TT4),free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),anti-thyroglobulin antibody(TgAb),thyroid peroxidase antibody(TPOAb),fasting blood glucose,glycosylated hemoglobin(HbA1c)and blood lipids among the three groups were analyzed.Results:There was no significant difference in thyroid function between the vitamin D deficient group and the vitamin D sufficient group(P>0.05),but the levels of TgAb,TPOAb,Cholesterol(TC),triglyceride(TG)and HbA1c in the vitamin D deficient group were higher than those in the vitamin D sufficient group(P<0.05).Correlation analysis showed that 25-OH-VD was negatively correlated with HbA1c,TT3,TgAb,TPOAb,TG,TC and sex(P<0.05).Logistic regression results found that sex and 25-OH-VD were the influencing factor of TPOAb positivity.Conclusions:Vitamin D deficiency is common in type 2 diabetes mellitus.The level of vitamin D deficiency is correlated with the level of HbA1c,moreover,high 25-OH-VD level is a protective factor for TPOAb positivity.
作者
李瑜
裴晓艳
于磊
汪琼
庄兰艮
金国玺
LI Yu;PEI Xiao-yan;YU Lei;WANG Qiong;ZHUANG Lan-gen;JIN Guo-xi(Department of Endocrinology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)
出处
《蚌埠医学院学报》
CAS
2023年第10期1366-1369,共4页
Journal of Bengbu Medical College
基金
安徽省高校自然科学研究重大项目(KJ2019ZD29)
蚌埠医学院自然科学重点项目(2021byzd043)。
