摘要
目的 分析尤瑞克林治疗急性脑梗死的疗效及对患者炎性反应物、血管内皮功能的影响。方法 100例急性脑梗死患者,以随机数字表法分为参照组和研究组,每组50例。参照组患者采用常规治疗,研究组患者在参照组基础上加用尤瑞克林治疗。对比两组患者临床疗效及治疗前后炎性反应物[C反应蛋白(CRP)]、血管内皮指标[血管内皮素-1(ET-1)、血管内皮生长因子(VEGF)]。结果 研究组患者总有效率94.00%,显著高于参照组的80.00%,差异有统计学意义(P<0.05)。治疗前,两组患者CRP、ET-1、VEGF水平对比,差异无统计学意义(P>0.05);治疗后,研究组患者CRP(9.45±2.07)mg/L、ET-1(48.42±5.33)ng/L明显低于参照组的(15.39±3.41)mg/L、(61.39±6.02)ng/L, VEGF(243.08±35.42)pg/ml明显高于参照组的(185.54±31.07)pg/ml,差异均有统计学意义(P<0.05)。结论 尤瑞克林用于急性脑梗死治疗优势显著,可提升临床疗效、降低炎性反应水平、改善血管内皮功能,促进病情康复,有推广应用价值。
Objective To analyze the efficacy of urinary kallidinogenase on patients with acute cerebral infarction and its influence on inflammatory reactants and vascular endothelial function.Methods A total of 100 patients with acute cerebral infarction were divided into reference group and study group according to the random numerical table,with 50 cases in each group.Patients in the reference group was treated with conventional treatment,and patients in the study group was treated with urinary kallidinogenase on the basis of the reference group.The clinical efficacy,inflammatory reactants[C-reactive protein(CRP)],vascular endothelial indicators[endothelin-1(ET-1)and vascular endothelial growth factor(VEGF)]before and after treatment were compared between the two groups.Results The total effective rate of the study group was 94.00%,which was significantly higher than that of 80.00%of the reference group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in levels of CRP,ET-1 and VEGF between the two groups(P>0.05).After treatment,CRP of(9.45±2.07)mg/L and ET-1 of(48.42±5.33)ng/L in the study group were significantly lower than those of(15.39±3.41)mg/L and(61.39±6.02)ng/L in the control group;VEGF of(243.08±35.42)pg/ml in the study group was significantly higher than that of(185.54±31.07)pg/ml in the reference group;the differences were statistically significant(P<0.05).Conclusion Urinary kallidinogenase has significant advantages in the treatment of acute cerebral infarction,which can improve clinical efficacy,down-regulate inflammatory response,improve endothelial function,and promote rehabilitation of the disease.It has the value of promotion and application.
作者
张月
ZHANG Yue(Department of Neurology,Jinzhou Central Hospital,Jinzhou 121000,China)
出处
《中国现代药物应用》
2023年第19期71-73,共3页
Chinese Journal of Modern Drug Application
关键词
急性脑梗死
尤瑞克林
炎性反应物
血管内皮功能
Acute cerebral infarction
Urinary kallidinogenase
Inflammatory reactants
Vascular endothelial function
