摘要
目的 分析四联疗法中不同剂量艾司奥美拉唑治疗老年幽门螺杆菌感染慢性胃炎的临床疗效。方法 选取郑州大学第二附属医院在2021年3月至2023年3月期间收治的92例老年幽门螺杆菌感染慢性胃炎患者作为研究对象,依据区间随机法将其分为对照组、研究组,各纳入46例,两组患者均接受四联疗法治疗(阿莫西林+克拉霉素+艾司奥美拉唑+胶体果胶铋),其中对照组艾司奥美拉唑1次1粒、1天2次(20 mg bid);研究组艾司奥美拉唑1次2粒、1天2次(40 mg bid)。围绕两组治疗有效率、基础症状消失时间、治疗前后胃肠功能量表评分[胃肠道症状评定量表(GSRS),尼平消化不良指数(NDI)]、治疗前后血清炎症因子指标展开对比分析及不良反应。结果 研究组治疗有效率(95.65%)高于对照组(78.26%),差异有统计学意义(P<0.05)。研究组腹痛、腹胀、厌食消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组GSRS、NDI评分对比,差异无统计学意义(P> 0.05);治疗后,两组GSRS、NDI评分较治疗前均有明显降低,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组间各炎症因子水平对比,差异无统计学意义(P> 0.05);治疗后,两组C反应蛋白(CRP)、降钙素原(PCT)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平较治疗前均明显降低,且研究组低于对照组,差异有统计学意义(P<0.05)。两组用药治疗期间不良反应发生率对比,差异无统计学意义(P> 0.05)。结论 老年幽门螺杆菌感染慢性胃炎采用高剂量艾司奥美拉唑四联疗法可取得较理想的治疗效果,在治疗有效率、安全性方面均有保障,值得应用。
Objective To analyze the clinical efficacy of quadruple therapy in elderly patients with helicobacter pylori infection-induced chronic gastritis.Methods 92 elderly patients with helicobacter pylori infection-induced chronic gastritis treated from March 2021 to March 2023 in our hospital were chosen as research subjects.According to the random interval method,patients were assigned to control group(n=46)and study group(n=46).Both of groups were served with quadruple therapy(amoxicillin,clarithromycin,esomeprazole and colloidal bismuth pectin granules.The control took a pill of esomeprazole once,two times a day(20mg bid);the study group took two pills of esomeprazole,two times a day(40mg bid).The total effective rates,basic symptom relief time,adverse reactions,gastrointestinal function indexes like gastrointestinal symptom rating scale(GSRS)and Nipin dyspepsia index(NDI),the serum inflammatory factors were compared.Results The treatment effectiveness rate of the research group(95.65%)was higher than that of the control group(78.26%),and the difference was statistically significant(P<0.05).The disappearance time of abdominal pain,bloating,and anorexia in the research group was shorter than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in GSRS and NDI scores between the two groups(P>0.05);after treatment,GSRS and NDI scores in both groups were significantly lower than before treatment,and those in the research group were lower than those in the control group,with a statistically significant difference(P<0.05).Before treatment,there was no significant difference in various inflammation factor levels between the two groups(P>0.05);after treatment,C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),tumor necrosis factorα(TNF-α)levels in both groups were significantly lower than before treatment,and those in the research group were lower than those in the control group,with a statistically significant difference(P<0.05).There was no significant difference in adverse reaction rates during medication treatment between the two groups(P>0.05)..Conclusion The quadruple therapy with high-dose esomeprazole can improve the treatment effectiveness and safety for elderly patients with helicobacter pylori infection-induced chronic gastritis.It is worthy of clinical application.
作者
王钰莹
张继佳
WANG Yuying ZHANG Jijia(Department of Geriatrics,the Second Affiliated Hospital of Zhengzhou University ZhengzhouHenan 450014)
出处
《临床研究》
2023年第11期109-112,共4页
Clinical Research
关键词
高剂量艾司奥美拉唑
四联疗法
老年幽门螺杆菌感染慢性胃炎
炎症因子
High-dose esomeprazole
quadruple therapy
helicobacter pylori infection-induced chronic gastritis
inflammatory factors
